In other species: dog , domestic cat , pig

Categories: Haematopoietic system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 277480 (trait) , 613160 (gene)

Single-gene trait/disorder: yes

Mode of inheritance: Probably autosomal recessive

Disease-related: yes

Key variant known: no

Cross-species summary: The von Willebrand factor (vWF) is a large multimeric plasma glycoprotein required for platelet adhesion and aggregation. A deficiency or defective vWF results in von Willebrand disease (vWD). vWD are often classified in 3 different types based on the clinical severity and quantity and multimere size of von Willebrand factor. Type I is characterized by low plasma vWF concentrations and mild to moderate bleeding symptoms. Type II disorder is characterised by qualitative abnormalities of the vWF protein and moderate to severe bleeding. Type III is the most severe form of vWD with no detectable or a severe quantitative deficiency of vWF.

Species summary: [IT thanks Alexandra Schaening for contributions to this entry in September 2026]

Species-specific symbol: vWD3

Clinical features: Patterson et al. (2002) reported an 8 month old rhesus monkey observed to be depressed and found to have intermittent hemorrhage of excessive volume and duration from small lacerations and tooth eruptions. Red blood cell and platelet counts obtained via CBC indicated a regenerative anemia with mild thrombocytopenia. Other clinical signs noted were epistaxis and the presence of a systolic murmur. Coagulation and vWF analyses revealed a prolonged APTT and no detectable vWF:Ag or vWF:Rcof resuling in a diagnosis of type 3 von Willebrand disease.