OMIA:001058-9685 : Von Willebrand disease III in Felis catus (domestic cat)
Categories: Haematopoietic system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal
Considered a defect: yes
Key variant known: no
Cross-species summary: The von Willebrand factor (vWF) is a large multimeric plasma glycoprotein required for platelet adhesion and aggregation. A deficiency or defective vWF results in von Willebrand disease (vWD). vWD are often classified in 3 different types based on the clinical severity and quantity and multimere size of von Willebrand factor. Type I is characterized by low plasma vWF concentrations and mild to moderate bleeding symptoms. Type II disorder is characterised by qualitative abnormalities of the vWF protein and moderate to severe bleeding. Type III is the most severe form of vWD with no detectable or a severe quantitative deficiency of vWF.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: vWD is rarely recognized in cats (Thomas 1996). French et al. (1987) diagnosed von Willebrand disease in a 9-year-old male Himalayan cat. The cat presented with persistent oral bleeding after routine dental extraction. Haematuria (blood in the urine), petechia, melena (black stools due to gastrointestinal bleeding) were also observed. Laboratory testing identified disseminated intravascular coagulation (thrombocytopenia, prolonged activated partial thromboplastin time, and increased fibrin degradation products) and recurring iron-deficiency anemia. Coagulation factor assays revealed low factor VIII coagulant activity and undetectable factor VIII-related antigen. The cat initially recovered after treatment but showed spontaneous gingival bleeding 8 month later. No history of abnormal bleeding existed for the cat's sire or dam.
[IT thanks DVM student Arianne Tash for suggested changes in April 2022]
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Haginoya, S., Thomovsky, E.J., Johnson, P.A., Brooks, A.C. :|
|Clinical assessment of primary hemostasis: A review. Top Companion Anim Med :100818, 2023. Pubmed reference: 37673175. DOI: 10.1016/j.tcam.2023.100818.|
|2012||Herring, J., McMichael, M. :|
|Diagnostic approach to small animal bleeding disorders. Top Companion Anim Med 27:73-80, 2012. Pubmed reference: 23031459. DOI: 10.1053/j.tcam.2012.07.004.|
|1996||Thomas, J.S. :|
|Von Willebrand's disease in the dog and cat Veterinary Clinics of North America - Small Animal Practice 26:1089 ff., 1996.|
|1987||French, T.W., Fox, L.E., Randolph, J.F., Dodds, W.J. :|
|A bleeding disorder (von Willebrand's disease) in a Himalayan cat. J Am Vet Med Assoc 190:437-9, 1987. Pubmed reference: 3104251.|
- Created by Frank Nicholas on 23 Apr 2013
- Changed by Imke Tammen2 on 23 Apr 2022