OMIA 001091-9823 : Ataxia, progressive in Sus scrofa |
In other species:
dog
,
cattle
Mendelian trait/disorder:
yes
Mode of inheritance:
Autosomal Recessive
Considered a defect:
yes
Key variant known:
no
Cross-species summary:
A progressive failure of muscle co-ordination, resulting in perverse movements
Species-specific name:
congenital progressive ataxia and spastic paresis
Species-specific symbol:
CPA
Species-specific description:
The central nervous system appears normal at birth, but older pigs show dysplasia of the cerebellar cortex. Rimaila-Parnanen (1982) provided convincing evidence of autosomal recessive inheritance
Markers:
y
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2009 | Genini, S., Nguyen, T.T., Bürgi, E., Stranzinger, G., Vögeli, P., Giuffra, E. : | |
Elimination of INPP4A and SLC5A7 as candidate genes for congenital progressive ataxia and spastic paresis in pigs. Anim Genet 40:789-90, 2009. Pubmed reference: 19397514. DOI: 10.1111/j.1365-2052.2009.01889.x. | ||
2007 | Genini, S., Kratzsch, A., Korczak, B., Neuenschwander, S., Brenig, B., Jörg, H., Bürgi, E., Ossent, P., Stranzinger, G., Vögeli, P. : | |
Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis. J Anim Breed Genet 124:269-76, 2007. Pubmed reference: 17868079. DOI: 10.1111/j.1439-0388.2007.00673.x. | ||
1999 | Kratzsch, A., Stricker, C., Gmur, C., Rieder, S., Jorg, H., Ossent, P., Burgi, E., Zimmermann, W., Stranzinger, G., Vogeli, P. : | |
Congenital progressive ataxia and spastic paresis, a hereditary disease in swine, maps to Chromosome 3 by linkage analysis Mammalian Genome 10:1036-1038, 1999. Pubmed reference: 10501979. | ||
1982 | Rimaila-Parnanen, E. : | |
Recessive mode of inheritance in progressive ataxia and incoordination in Yorkshire pigs Hereditas 97:305-306, 1982. |
Edit History
- Created by Frank Nicholas on 01 Dec 2009