OMIA 001114-9615 : Nephritis, autosomal dominant in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s) (MIM number): 104200 (trait)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: yes

Key variant known: no

Species-specific description: The first report of this disorder in dogs was in Bull Terriers, by Hood et al. (1990). The same disorder in Dalmations was reported by Hood et al. (2002) [FN 13 Jan 2003]


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2002 Hood, J.C., Huxtable, C., Naito, I., Smith, C., Sinclair, R., Savige, J. :
A novel model of autosomal dominant Alport syndrome in Dalmatian dogs Nephrology Dialysis Transplantation 17:2094-2098, 2002.
Hood, JC., Dowling, J., Bertram, JF., Young, RJ., Huxtable, C., Robinson, W., Savige, J. :
Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers. Nephrol Dial Transplant 17:1897-908, 2002. Pubmed reference: 12401844.
Kashtan, C.E. :
Animal models of Alport syndrome. Nephrol Dial Transplant 17:1359-62, 2002. Pubmed reference: 12147777. DOI: 10.1093/ndt/17.8.1359.
2000 Hood, JC., Savige, J., Seymour, AE., Dowling, J., Martinello, P., Colville, D., Sinclair, R., Naito, I., Jennings, G., Huxtable, C. :
Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis. Am J Kidney Dis 36:378-91, 2000. Pubmed reference: 10922317. DOI: 10.1053/ajkd.2000.8989.
1995 Hood, J.C., Savige, J., Hendtlass, A., Kleppel, M.M., Huxtable, C.R., Robinson, W.F. :
Bull terrier hereditary nephritis: A model for autosomal dominant alport syndrome Kidney International 47:758-765, 1995. Pubmed reference: 7752574.
1994 Hood, JC., Craig, AJ. :
Hereditary nephritis in a miniature bull terrier. Vet Rec 135:138-40, 1994. Pubmed reference: 7975107.
1991 Hood, J.C., Robinson, W.F., Clark, W.T., Sutherland, R.J., James, I., Thomas, M.A.B., Huxtable, C.R. :
Proteinuria As an Indicator of Early Renal Disease in Bull Terriers with Hereditary Nephritis Journal of Small Animal Practice 32:241-248, 1991.
1990 Hood, J.C., Robinson, W.F., Huxtable, C.R., Bradley, J.S., Sutherland, R.J., Thomas, M.A.B. :
Hereditary Nephritis in the Bull Terrier - Evidence for Inheritance by an Autosomal Dominant Gene Veterinary Record 126:456-459, 1990. Pubmed reference: 2356601.

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  • Created by Frank Nicholas on 06 Sep 2005