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OMIA:001120-9615 : Myelopathy, fibrocartilaginous embolic in Canis lupus familiaris (dog)

In other species: horse

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Fibrocartilaginous embolic myelopathy results from the blocking of blood vessels that supply blood to the spinal with microscopic pieces of an intervertebral disc.

Species-specific name: fibrocartilaginous embolism, FCE

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Bernese Mountain Dog (Dog) (VBO_0200161), Boxer (Dog) (VBO_0200210), Doberman Pinscher (Dog) (VBO_0200442), German Shepherd Dog (Dog) (VBO_0200577), Golden Retriever (Dog) (VBO_0200610), Great Dane (Dog) (VBO_0200623), Irish Wolfhound (Dog) (VBO_0200706), Labrador Retriever (Dog) (VBO_0200800), Miniature Schnauzer (Dog) (VBO_0200896), Rottweiler (Dog) (VBO_0201143), Shetland Sheepdog (Dog) (VBO_0201217), Staffordshire Bull Terrier (Dog) (VBO_0201296), Yorkshire Terrier (Dog) (VBO_0201448).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001120-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Embersics, C., Bannasch, D., Batcher, K., Boudreau, E.C., Church, M., Miller, A., Platt, S., Koehler, J., Olby, N., Rossmeisl, J., Rissi, D., Grahn, R., Donner, J., Dickinson, P.J. :
Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs. J Vet Intern Med , 2023. Pubmed reference: 37916855. DOI: 10.1111/jvim.16925.
2018 Martens, S.M., Nykamp, S.G., James, F.M.K. :
Magnetic resonance imaging muscle lesions in presumptive canine fibrocartilaginous embolic myelopathy. Can Vet J 59:1287-1292, 2018. Pubmed reference: 30532285.
2016 Bartholomew, K.A., Stover, K.E., Olby, N.J., Moore, S.A. :
Clinical characteristics of canine fibrocartilaginous embolic myelopathy (FCE): a systematic review of 393 cases (1973-2013). Vet Rec 179:650, 2016. Pubmed reference: 27682506. DOI: 10.1136/vr.103863.
Fenn, J., Drees, R., Volk, H.A., De Decker, S. :
Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute noncompressive nucleus pulposus extrusion. J Am Vet Med Assoc 249:767-75, 2016. Pubmed reference: 27654163. DOI: 10.2460/javma.249.7.767.
2007 De Risio, L., Adams, V., Dennis, R., McConnell, F., Platt, S. :
Magnetic resonance imaging findings and clinical associations in 52 dogs with suspected ischemic myelopathy. J Vet Intern Med 21:1290-8, 2007. Pubmed reference: 18196739. DOI: 10.1892/06-273.1.
2001 Hawthorne, J.C., Wallace, L.J., Fenner, W.R., Waters, D.J. :
Fibrocartilaginous embolic myelopathy in miniature schnauzers. J Am Anim Hosp Assoc 37:374-83, 2001. Pubmed reference: 11450839. DOI: 10.5326/15473317-37-4-374.
2000 Junker, K., van den Ingh, T.S., Bossard, M.M., van Nes, J.J. :
Fibrocartilaginous embolism of the spinal cord (FCE) in juvenile Irish Wolfhounds. Vet Q 22:154-6, 2000. Pubmed reference: 10952446. DOI: 10.1080/01652176.2000.9695046.
1996 Cauzinille, L., Kornegay, J.N. :
Fibrocartilaginous embolism of the spinal cord in dogs: review of 36 histologically confirmed cases and retrospective study of 26 suspected cases. J Vet Intern Med 10:241-5, 1996. Pubmed reference: 8819049. DOI: 10.1111/j.1939-1676.1996.tb02056.x.
1992 Neer, T.M. :
Fibrocartilaginous emboli. Vet Clin North Am Small Anim Pract 22:1017-26, 1992. Pubmed reference: 1641914. DOI: 10.1016/s0195-5616(92)50090-0.
1988 Cook, J.R. :
Fibrocartilaginous embolism. Vet Clin North Am Small Anim Pract 18:581-92, 1988. Pubmed reference: 3289246. DOI: 10.1016/s0195-5616(88)50056-6.
1974 Zaki, F.A., Prata, R.G., Kay, W.J. :
Necrotizing myelopathy in five great danes. J Am Vet Med Assoc 165:1080-4, 1974. Pubmed reference: 4474152.
1973 Griffiths, I.R. :
Spinal cord infarction due to emboli arising from the intervertebral discs in the dog. J Comp Pathol 83:225-32, 1973. Pubmed reference: 4128372. DOI: 10.1016/0021-9975(73)90046-7.

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  • Created by Imke Tammen2 on 05 Nov 2023
  • Changed by Imke Tammen2 on 05 Nov 2023