OMIA 001125-9913 : Ketosis in Bos taurus

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Cainzos, J.M., Andreu-Vazquez, C., Guadagnini, M., Rijpert-Duvivier, A., Duffield, T. :
A systematic review of the cost of ketosis in dairy cattle. J Dairy Sci 105:6175-6195, 2022. Pubmed reference: 35534272. DOI: 10.3168/jds.2021-21539.
Loiklung, C., Sukon, P., Thamrongyoswittayakul, C. :
Global prevalence of subclinical ketosis in dairy cows: A systematic review and meta-analysis. Res Vet Sci 144:66-76, 2022. Pubmed reference: 35077992. DOI: 10.1016/j.rvsc.2022.01.003.
2020 Freebern, E., Santos, D.J.A., Fang, L., Jiang, J., Parker Gaddis, K.L., Liu, G.E., VanRaden, P.M., Maltecca, C., Cole, J.B., Ma, L. :
GWAS and fine-mapping of livability and six disease traits in Holstein cattle. BMC Genomics 21:41, 2020. Pubmed reference: 31931710. DOI: 10.1186/s12864-020-6461-z.
Lopes, F., Rosa, G., Pinedo, P., Santos, J.E.P., Chebel, R.C., Galvao, K.N., Schuenemann, G.M., Bicalho, R.C., Gilbert, R.O., Rodrigez-Zas, S., Seabury, C.M., Thatcher, W. :
Genome-enable prediction for health traits using high-density SNP panel in US Holstein cattle. Anim Genet :, 2020. Pubmed reference: 31909828. DOI: 10.1111/age.12892.
Yan, Z., Huang, H., Freebern, E., Santos, D.J.A., Dai, D., Si, J., Ma, C., Cao, J., Guo, G., Liu, G.E., Ma, L., Fang, L., Zhang, Y. :
Integrating RNA-Seq with GWAS reveals novel insights into the molecular mechanism underpinning ketosis in cattle. BMC Genomics 21:489, 2020. Pubmed reference: 32680461. DOI: 10.1186/s12864-020-06909-z.
2019 Huang, H., Cao, J., Hanif, Q., Wang, Y., Yu, Y., Zhang, S., Zhang, Y. :
Genome-wide association study identifies energy metabolism genes for resistance to ketosis in Chinese Holstein cattle. Anim Genet 50:376-380, 2019. Pubmed reference: 31179571. DOI: 10.1111/age.12802.
Klein, S.L., Scheper, C., Brügemann, K., Swalve, H.H., König, S. :
Phenotypic relationships, genetic parameters, genome-wide associations, and identification of potential candidate genes for ketosis and fat-to-protein ratio in German Holstein cows. J Dairy Sci 102:6276-6287, 2019. Pubmed reference: 31056336. DOI: 10.3168/jds.2019-16237.
Weller, J.I., Ezra, E., van Straten, M. :
Genetic and environmental analysis of diseases with major economic impact in Israeli Holsteins. J Dairy Sci 102:10030-10038, 2019. Pubmed reference: 31521347. DOI: 10.3168/jds.2018-16026.
2018 Kroezen, V., Schenkel, F.S., Miglior, F., Baes, C.F., Squires, E.J. :
Candidate gene association analyses for ketosis resistance in Holsteins. J Dairy Sci :, 2018. Pubmed reference: 29550117. DOI: 10.3168/jds.2017-13374.
2012 Neuenschwander, T.F., Miglior, F., Jamrozik, J., Berke, O., Kelton, D.F., Schaeffer, L.R. :
Genetic parameters for producer-recorded health data in Canadian Holstein cattle. Animal 6:571-8, 2012. Pubmed reference: 22436272. DOI: 10.1017/S1751731111002059.
2011 Stengärde, L., Holtenius, K., Emanuelson, U., Hultgren, J., Niskanen, R., Tråvén, M. :
Blood parameters in Swedish dairy herds with high or low incidence of displaced abomasum or ketosis. Vet J 190:124-30, 2011. Pubmed reference: 21982532. DOI: 10.1016/j.tvjl.2010.09.011.
2009 Appuhamy, J.A., Cassell, B.G., Cole, J.B. :
Phenotypic and genetic relationships of common health disorders with milk and fat yield persistencies from producer-recorded health data and test-day yields. J Dairy Sci 92:1785-95, 2009. Pubmed reference: 19307662. DOI: 10.3168/jds.2008-1591.
2007 Morris, C.A. :
A review of genetic resistance to disease in Bos taurus cattle. Vet J 174:481-91, 2007. Pubmed reference: 17095270. DOI: 10.1016/j.tvjl.2006.09.006.
2005 Heringstad, B., Chang, Y.M., Gianola, D., Klemetsdal, G. :
Genetic analysis of clinical mastitis, milk fever, ketosis, and retained placenta in three lactations of Norwegian red cows. J Dairy Sci 88:3273-81, 2005. Pubmed reference: 16107417. DOI: 10.3168/jds.S0022-0302(05)73010-1.
Padilla, L., Shibano, K., Inoue, J., Matsui, T., Yano, H. :
Plasma vitamin C concentration is not related to the incidence of ketosis in dairy cows during the early lactation period. J Vet Med Sci 67:883-6, 2005. Pubmed reference: 16210799.
2004 Zwald, N.R., Weigel, K.A., Chang, Y.M., Welper, R.D., Clay, J.S. :
Genetic selection for health traits using producer-recorded data. II. Genetic correlations, disease probabilities, and relationships with existing traits. J Dairy Sci 87:4295-302, 2004. Pubmed reference: 15545393. DOI: 10.3168/jds.S0022-0302(04)73574-2.
Zwald, N.R., Weigel, K.A., Chang, Y.M., Welper, R.D., Clay, J.S. :
Genetic selection for health traits using producer-recorded data. I. Incidence rates, heritability estimates, and sire breeding values. J Dairy Sci 87:4287-94, 2004. Pubmed reference: 15545392. DOI: 10.3168/jds.S0022-0302(04)73573-0.
2000 Duffield, T. :
Subclinical ketosis in lactating dairy cattle Veterinary Clinics of North America - Food Animal Practice 16:231-+, 2000.
Gerloff, B.J. :
Dry cow management for the prevention of ketosis and fatty liver in dairy cows Veterinary Clinics of North America - Food Animal Practice 16:283-+, 2000.
Hippen, A.R. :
Glucagon as a potential therapy for ketosis and fatty liver Veterinary Clinics of North America - Food Animal Practice 16:267-+, 2000.
1999 Hansen, P.W. :
Screening of dairy cows for ketosis by use of infrared spectroscopy and multivariate calibration Journal of Dairy Science 82:2005-2010, 1999. Pubmed reference: 10509260. DOI: 10.3168/jds.S0022-0302(99)75437-8.
Mottram, T.T., Dobbelaar, P., Schukken, Y.H., Hobbs, P.J., Bartlett, P.N. :
An experiment to determine the feasibility of automatically detecting hyperketonaemia in dairy cows Livestock Production Science 61:7-11, 1999.
Rasmussen, L.K., Nielsen, B.L., Pryce, J.E., Mottram, T.T., Veerkamp, R.F. :
Risk factors associated with the incidence of ketosis in dairy cows Animal Science 68:379-386, 1999.
van Dorp, R.T.E., Martin, S.W., Shoukri, M.M., Noordhuizen, J.P.T.M., Dekkers, J.C.M. :
An epidemiologic study of disease in 32 registered Holstein dairy herds in British Columbia Canadian Journal of Veterinary Research - Revue Canadienne de Recherche Veterinaire 63:185-192, 1999. Pubmed reference: 10480460.
1998 Itoh, N., Koiwa, M., Hatsugaya, A., Yokota, H., Taniyama, H., Okada, H., Kudo, K. :
Comparative analysis of blood chemical values in primary ketosis and abomasal displacement in cows Zentralblatt Fur Veterinarmedizin - Reihe A 45:293-298, 1998. Pubmed reference: 9719761.
Kelton, D.F., Lissemore, K.D., Martin, R.E. :
Recommendations for recording and calculating the incidence of selected clinical diseases of dairy cattle Journal of Dairy Science 81:2502-2509, 1998. Pubmed reference: 9785242. DOI: 10.3168/jds.S0022-0302(98)70142-0.
Kochnev, N.N., Ernst, L.K., Petukhov, V.L., Zheltikov, A.I., Nezavitin, A.G., Marenkov, V.G. :
[Genetics of ketosis resistance in cattle]. Genetika 34:285-9, 1998. Pubmed reference: 9589856.
Nakagawa, H., Katoh, N. :
Reduced activity of lecithin : cholesterol acyltransferase in the serum of cows with ketosis and left displacement of the abomasum Veterinary Research Communications 22:517-524, 1998. Pubmed reference: 10066125.
Van Dorp, T.E., Dekkers, J.C., Martin, S.W., Noordhuizen, J.P. :
Genetic parameters of health disorders, and relationships with 305-day milk yield and conformation traits of registered Holstein cows. J Dairy Sci 81:2264-70, 1998. Pubmed reference: 9749393. DOI: 10.3168/jds.S0022-0302(98)75806-0.
1997 Horvat, J.A., Jovanovic, M.J. :
The concentration of glucose, total bilirubin and free fatty acids in the blood and of acetone bodies in the urine of healthy and ketotic cows before and after calving Acta Veterinaria-Beograd 47:293-301, 1997.
Nikolic, J.A., Samanc, H., Begovic, J., Damjanovic, Z., Dokovic, R., Kostic, G., Krsmanovic, J., Resanovic, V. :
Low peripheral serum thyroid hormone status independently affects the hormone profile of healthy and ketotic cows during the first week post partum Acta Veterinaria 47:3-13, 1997.
Oikawa, S., Katoh, N., Kawawa, F., Ono, Y. :
Decreased serum apolipoprotein B-100 and a-i concentrations in cows with ketosis and left displacement of the abomasum American Journal of Veterinary Research 58:121-125, 1997. Pubmed reference: 9028472.
Steen, A., Gronstol, H., Torjesen, P.A. :
Glucose and insulin responses to glucagon injection in dairy cows with ketotis and fatty liver Zentralblatt Fur Veterinarmedizin - Reihe A 44:521-530, 1997. Pubmed reference: 9465772.
1996 Dobbelaar, P., Mottram, T., Nyabadza, C., Hobbs, P., Elliottmartin, R.J., Schukken, Y.H. :
Detection of ketosis in dairy cows by analysis of exhaled breath Veterinary Quarterly 18:151-152, 1996. Pubmed reference: 8972064.
Shpigel, N.Y., Chen, R., Avidar, Y., Bogin, E. :
Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows Journal of the American Veterinary Medical Association 208:1702 ff., 1996.
1995 Uribe, H.A., Kennedy, B.W., Martin, S.W., Kelton, D.F. :
Genetic parameters for common health disorders of Holstein cows. J Dairy Sci 78:421-30, 1995. Pubmed reference: 7745163. DOI: 10.3168/jds.S0022-0302(95)76651-6.
1991 Klug, F., Franz, H. :
Breeding Aspects Relating to Occurrence of Ketosis in Dairy Cow Monatshefte Fur Veterinarmedizin 46:573-575, 1991.
Mantysaari, E.A., Grohn, Y.T., Quaas, R.L. :
Clinical Ketosis - Phenotypic and Genetic Correlations Between Occurrences and with Milk Yield Journal of Dairy Science 74:3985-3993, 1991. Pubmed reference: 1757637. DOI: 10.3168/jds.S0022-0302(91)78593-7.
Simianer, H., Solbu, H., Schaeffer, L.R. :
Estimated genetic correlations between disease and yield traits in dairy cattle. J Dairy Sci 74:4358-65, 1991. Pubmed reference: 1787205. DOI: 10.3168/jds.S0022-0302(91)78632-3.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 16 Apr 2012
  • Changed by Imke Tammen2 on 03 Dec 2020
  • Changed by Imke Tammen2 on 26 Aug 2021
  • Changed by Imke Tammen2 on 11 Sep 2022