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OMIA:001178-9615 : Stomatocytosis and gastritis in Canis lupus familiaris (dog)

Categories: Haematopoietic system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 185000 (trait) , 194380 (trait) , 185020 (trait)

Single-gene trait/disorder: unknown

Disease-related: yes

Cross-species summary: Abnormal red blood cell morphology (central zone of pallor has a 'mouthlike' pattern) and hypertrophic gastritis

Species-specific name: Familial stomatocytosis hypertrophic gastritis

Clinical features: Slappendel et al. (1991): "The main clinical problems were diarrhoea, icterus, and ataxia and paresis of the pelvic limbs. Laboratory evaluation revealed abnormal red cell shape (stomatocytosis), increased osmotic fragility, haemolytic anaemia, and increased liver enzymes and serum bilirubin. Gastroscopic and histopathologic examination of the gastric mucosa revealed hypertrophic gastritis resembling Ménétrier's disease in man. ... Electroneurography in 2 dogs revealed polyneuropathy."

Pathology: Slappendel et al. (1991): "Histologic findings in the liver were suggestive of progressive liver disease. Cysts were found in the kidneys of the five oldest patients."

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:001178-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1994 Slappendel, R.J., Renooij, W., de Bruijne, J.J. :
Normal cations and abnormal membrane lipids in the red blood cells of dogs with familial stomatocytosis-hypertrophic gastritis. Blood 84:904-9, 1994. Pubmed reference: 8043871.
1991 Slappendel, R.J., van der Gaag, I., van Nes, J.J., van den Ingh, T.S., Happé, R.P. :
Familial stomatocytosis--hypertrophic gastritis (FSHG), a newly recognised disease in the dog (Drentse patrijshond). Vet Q 13:30-40, 1991. Pubmed reference: 2021052. DOI: 10.1080/01652176.1991.9694282.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 23 Oct 2022
  • Changed by Imke Tammen2 on 15 Apr 2025