OMIA:001178-9615 : Stomatocytosis and gastrits in Canis lupus familiaris
Categories: Haematopoietic system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 185000 (trait) , 194380 (trait) , 185020 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Abnormal red blood cell morphology (central zone of pallor has a 'mouthlike' pattern) and hypertrophic gastritis
Species-specific name: Familial stomatocytosis hypertrophic gastritis
Clinical features: Slappendel et al. (1991): "The main clinical problems were diarrhoea, icterus, and ataxia and paresis of the pelvic limbs. Laboratory evaluation revealed abnormal red cell shape (stomatocytosis), increased osmotic fragility, haemolytic anaemia, and increased liver enzymes and serum bilirubin. Gastroscopic and histopathologic examination of the gastric mucosa revealed hypertrophic gastritis resembling Ménétrier's disease in man. ... Electroneurography in 2 dogs revealed polyneuropathy."
Pathology: Slappendel et al. (1991): "Histologic findings in the liver were suggestive of progressive liver disease. Cysts were found in the kidneys of the five oldest patients."
|1991||Slappendel, R.J., van der Gaag, I., van Nes, J.J., van den Ingh, T.S., Happé, R.P. :|
|Familial stomatocytosis--hypertrophic gastritis (FSHG), a newly recognised disease in the dog (Drentse patrijshond). Vet Q 13:30-40, 1991. Pubmed reference: 2021052 . DOI: 10.1080/01652176.1991.9694282.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 23 Oct 2022