OMIA:001181-9796 : Atrial fibrillation in Equus caballus (horse)

In other species: dog

Categories: Cardiovascular system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 194200 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: Physick-Sheard et al. (2014) concluded that atrial fibrillation (AF) in Standardbreds is multifactorial and reported that "Heritability of AF on the underlying scale (h²(u)) was estimated at 29.6 ± 3.9% and on the observed binomial scale (h²(o)), at 9.6%."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: American Trotter (Horse) (VBO_0000899).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:001181-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Vernemmen, I., Van Steenkiste, G., Decloedt, A., Meert, H., Walser, U., van Loon, G. :
Detection of paroxysmal atrial fibrillation preceding persistent atrial fibrillation in a horse using an implantable loop recorder with remote monitoring. J Vet Cardiol 52:S1760-2734(24)00005-5:19-27, 2024. Pubmed reference: 38402667. DOI: 10.1016/j.jvc.2024.02.002.
2023 Carstensen, H., Nissen, S.D., Saljic, A., Hesselkilde, E.M., van Hunnik, A., Hohl, M., Sattler, S.M., Fløgstad, C., Hopster-Iversen, C., Verheule, S., Böhm, M., Schotten, U., Jespersen, T., Buhl, R. :
Long-Term Training Increases Atrial Fibrillation Sustainability in Standardbred Racehorses. J Cardiovasc Transl Res , 2023. Pubmed reference: 37014465. DOI: 10.1007/s12265-023-10378-6.
Hansen, S., Otten, N.D., Nissen, S.D., Carstensen, H., Hopster-Iversen, C., Fjeldborg, J., Staun, S.H., Fenner, M., Hesselkilde, E.M., Buhl, R. :
Atrial fibrillation as a risk factor for exercise-induced pulmonary haemorrhage following a standardised exercise test. Equine Vet J , 2023. Pubmed reference: 37654233. DOI: 10.1111/evj.13995.
2022 Burns, J.J., MacMillan, K.M., John, E.E. :
Retrospective review of atrial fibrillation in Standardbred racehorses at a tertiary care facility in Atlantic Canada. Can Vet J 63:1051-1056, 2022. Pubmed reference: 36185789.
2021 Decloedt, A., Van Steenkiste, G., Vera, L., Buhl, R., van Loon, G. :
Atrial fibrillation in horses Part 2: Diagnosis, treatment and prognosis. Vet J 268:105594, 2021. Pubmed reference: 33468306. DOI: 10.1016/j.tvjl.2020.105594.
2020 Decloedt, A., Van Steenkiste, G., Vera, L., Buhl, R., van Loon, G. :
Atrial fibrillation in horses part 1: Pathophysiology. Vet J 263:105521, 2020. Pubmed reference: 32928494. DOI: 10.1016/j.tvjl.2020.105521.
Schüttler, D., Bapat, A., Kääb, S., Lee, K., Tomsits, P., Clauss, S., Hucker, W.J. :
Animal models of atrial fibrillation. Circ Res 127:91-110, 2020. Pubmed reference: 32716814. DOI: 10.1161/CIRCRESAHA.120.316366.
2018 Kraus, M., Physick-Sheard, P., Brito, L.F., Sargolzaei, M., Schenkel, F.S. :
Marginal ancestral contributions to atrial fibrillation in the Standardbred racehorse: Comparison of cases and controls. PLoS One 13:e0197137, 2018. Pubmed reference: 29763439. DOI: 10.1371/journal.pone.0197137.
2016 Navas de Solís, C., Reef, V.B., Slack, J., Jose-Cunilleras, E. :
Evaluation of coagulation and fibrinolysis in horses with atrial fibrillation. J Am Vet Med Assoc 248:201-6, 2016. Pubmed reference: 26720087. DOI: 10.2460/javma.248.2.201.
2014 Physick-Sheard, P., Kraus, M., Basrur, P., McGurrin, K., Kenney, D., Schenkel, F. :
Breed predisposition and heritability of atrial fibrillation in the Standardbred horse: a retrospective case-control study. J Vet Cardiol 16:173-84, 2014. Pubmed reference: 25087649. DOI: 10.1016/j.jvc.2014.03.006.
2009 Jesty, S.A., Kraus, M.S., Kraus, M., Gelzer, A.R., Gelzer, A., Rishniw, M., Moise, N.S., Moïse, N.S. :
Effect of transvenous electrical cardioversion on plasma cardiac troponin I concentrations in horses with atrial fibrillation. J Vet Intern Med 23:1103-7, 2009. Pubmed reference: 19678887. DOI: 10.1111/j.1939-1676.2009.0369.x.
2003 Ohmura, H., Hiraga, A., Takahashi, T., Kai, M., Jones, J.H. :
Risk factors for atrial fibrillation during racing in slow-finishing horses Journal of the American Veterinary Medical Association 223:84-8, 2003. Pubmed reference: 12839069.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 16 Apr 2015
  • Changed by Imke Tammen2 on 16 Sep 2021
  • Changed by Imke Tammen2 on 25 Nov 2022