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OMIA:001181-9925 : Atrial fibrillation in Capra hircus (goat)

In other species: dog , horse

Categories: Cardiovascular system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 194200 (trait)

Single-gene trait/disorder: yes

Disease-related: yes

Key variant known: no

Species-specific description: Polejaeva et al. (2016) established a transgenic goat model of atrial fibrosis with cardiac specific overexpression of TGFB1 to study the relationship between structural and electrical remodeling in atrial fibrillation. This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TGFB1 transforming growth factor beta 1 Capra hircus 18 NC_030825.1 (51434470..51418423) TGFB1 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:001181-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Kwan, E., Ghafoori, E., Good, W., Regouski, M., Moon, B., Fish, J.M., Hsu, E., Polejaeva, I.A., MacLeod, R.S., Dosdall, D.J., Ranjan, R. :
Diffuse functional and structural abnormalities in fibrosis: Potential structural basis for sustaining atrial fibrillation. Heart Rhythm , 2024. Pubmed reference: 39566810. DOI: 10.1016/j.hrthm.2024.10.060.
2019 Regouski, M., Galenko, O., Doleac, J., Olsen, A.L., Jacobs, V., Liechty, D., White, K.L., Bunch, T.J., Lee, P.M., Rutigliano, H.M., Polejaeva, I.A., Cutler, M.J. :
Spontaneous atrial fibrillation in transgenic goats with TGF (Transforming Growth Factor)-β1 induced atrial myopathy with endurance exercise. Circ Arrhythm Electrophysiol 12:e007499, 2019. Pubmed reference: 31707807. DOI: 10.1161/CIRCEP.119.007499.
2016 Polejaeva, I.A., Ranjan, R., Davies, C.J., Regouski, M., Hall, J., Olsen, A.L., Meng, Q., Rutigliano, H.M., Dosdall, D.J., Angel, N.A., Sachse, F.B., Seidel, T., Thomas, A.J., Stott, R., Panter, K.E., Lee, P.M., Van Wettere, A.J., Stevens, J.R., Wang, Z., MacLeod, R.S., Marrouche, N.F., White, K.L. :
Increased susceptibility to atrial fibrillation secondary to atrial fibrosis in transgenic goats expressing Transforming Growth Factor-β1. J Cardiovasc Electrophysiol 27:1220-1229, 2016. Pubmed reference: 27447370. DOI: 10.1111/jce.13049.

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  • Created by Imke Tammen2 on 02 May 2025