OMIA 001213-9986 : Premature senesence in Oryctolagus cuniculus

Possibly relevant human trait(s) and/or gene(s) (MIM number): 150330

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: Premature aging syndrome

Species-specific description: This affected rabbits produced by Sui et al. (2019) are the result of "precise LMNA targeting in rabbits via co-injection of Cas9/sgRNA mRNA into zygotes", i.e. it is a knock-out model of human premature aging inherited disorders. As such it is a genetically-modified organism (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
LMNA lamin A/C Oryctolagus cuniculus 13 NC_013681.1 (36745668..36727103) LMNA Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Sui, T., Liu, D., Liu, T., Deng, J., Chen, M., Xu, Y., Song, Y., Ouyang, H., Lai, L., Li, Z. :
<i>LMNA</i>-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy. Aging Dis 10:102-115, 2019. Pubmed reference: 30705772. DOI: 10.14336/AD.2018.0209.
1960 Pearce, L., Brown, W.H. :
Hereditary premature sensescence of the rabbit. I. Chronic form; general features. J Exp Med 111:485-504, 1960. Pubmed reference: 13733754.
Pearce, L., Brown, W.H. :
Hereditary premature senescence of the rabbit. II. Acute form; general features. J Exp Med 111:505-16, 1960. Pubmed reference: 13733753.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 12 Feb 2019