OMIA 001213-9986 : Premature senesence in Oryctolagus cuniculus

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 150330 (gene) , 176670 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: Progeria, Progeria Syndrome

Species-specific name: Premature aging syndrome

Species-specific description: This affected rabbits produced by Sui et al. (2019) are the result of "precise LMNA targeting in rabbits via co-injection of Cas9/sgRNA mRNA into zygotes", i.e. it is a knock-out model of human premature aging inherited disorders.

The affected rabbits described by Liu et al. (2018, 2020) are generated by genome editing and are considered genetically-modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
LMNA lamin A/C Oryctolagus cuniculus 13 NC_013681.1 (36745668..36727103) LMNA Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Liu, Z., Chen, S., Shan, H., Jia, Y., Chen, M., Song, Y., Lai, L., Li, Z. :
Efficient base editing with high precision in rabbits using YFE-BE4max. Cell Death Dis 11:36, 2020. Pubmed reference: 31959743. DOI: 10.1038/s41419-020-2244-3.
2019 Sui, T., Liu, D., Liu, T., Deng, J., Chen, M., Xu, Y., Song, Y., Ouyang, H., Lai, L., Li, Z. :
LMNA-mutated rabbits: A model of premature aging syndrome with muscular dystrophy and dilated cardiomyopathy. Aging Dis 10:102-115, 2019. Pubmed reference: 30705772. DOI: 10.14336/AD.2018.0209.
2018 Liu, Z., Chen, M., Chen, S., Deng, J., Song, Y., Lai, L., Li, Z. :
Highly efficient RNA-guided base editing in rabbit. Nat Commun 9:2717, 2018. Pubmed reference: 30006570. DOI: 10.1038/s41467-018-05232-2.
1960 Pearce, L., Brown, W.H. :
Hereditary premature sensescence of the rabbit. I. Chronic form; general features. J Exp Med 111:485-504, 1960. Pubmed reference: 13733754.
Pearce, L., Brown, W.H. :
Hereditary premature senescence of the rabbit. II. Acute form; general features. J Exp Med 111:505-16, 1960. Pubmed reference: 13733753.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 12 Feb 2019
  • Changed by Imke Tammen2 on 26 Jan 2021
  • Changed by Imke Tammen2 on 28 Jan 2021