OMIA:001252-8843 : Feather colour, recessive white in Anser anser (domestic goose) |
In other species: rock pigeon , chicken , common canary
Categories: Pigmentation phene
Single-gene trait/disorder: yes
Mode of inheritance: Autosomal co-dominant
Disease-related: no
Key variant known: yes
Year key variant first reported: 2020
Molecular basis: Xi et al. (2020) identified "a 14-bp insertion (NW_013185915.1: g. 750,748–750,735 insertion. CACAGGTGAGCTCT) in exon 3 of EDNRB2 . . . [that] was homozygous in all the white geese we detected and heterozygous in gray geese, indicating that this mutation is recessive. Furthermore, this 14-bp insertion leads to a frameshift mutation in the EDNRB2 coding region and nonsense-mediated mRNA decay." Yang et al. (2024) report that "the gray plumage color was codominant to the white color in [Wugangtong] WGT geese, and plumage color variations were controlled by EDNRB2. ... Sanger sequencing of the region surrounding the EDNRB2 gene identified a 14-bp insertion within exon 3 [previously reported by Xi et al. 2020] as the causal mutation. The heterozygosity of this 14-bp insertion and wild-type alleles was completely associated with the Wb phenotype [grey with white breast circle], thereby substantiating the codominant nature of the G [solid grey] and W [white] phenotypes."
Breeds:
Gang, China (Goose (domestic)) (VBO_0009987),
Wugang Copper, China (Goose (domestic)) (VBO_0009999).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
EDNRB2 | Anser anser | - | no genomic information (-..-) | EDNRB2 | Ensembl |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1164 | Gang, China (Goose (domestic)) | Feather colour, recessive white | EDNRB2 | insertion, small (<=20) | Naturally occurring variant | AnsCyg_PRJNA183603_v1.0 | NW_013185915.1:g.750748_750735insCACAGGTGAGCTCT | 2020 | 32066369 |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001252-8843: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2024 | Yang, Y., Wang, H., Liu, Y., Zhai, S., Liu, H., He, D. : |
A novel codominant plumage color pattern of white breast patches in WugangTong geese was controlled by EDNRB2. Poult Sci 103:S0032-5791(24)00903-9:104324, 2024. Pubmed reference: 39353325. DOI: 10.1016/j.psj.2024.104324. | |
2020 | Xi, Y., Wang, L., Liu, H., Ma, S., Li, Y., Li, L., Wang, J., Chunchun, H., Bai, L., Mustafa, A., He, H. : |
A 14-bp insertion in endothelin receptor B-like (EDNRB2) is associated with white plumage in Chinese geese. BMC Genomics 21:162, 2020. Pubmed reference: 32066369. DOI: 10.1186/s12864-020-6562-8. |
Edit History
- Created by Frank Nicholas on 25 Feb 2020
- Changed by Frank Nicholas on 25 Feb 2020
- Changed by Imke Tammen2 on 04 Oct 2024