OMIA 001254-9031 : Diplopodia-4 in Gallus gallus

Mendelian trait/disorder: yes

Mode of inheritance: Z-linked recessive

Considered a defect: yes

Key variant known: no

Species-specific symbol: dp-4

Mapping: Robb et al. (2011) mapped this trait to chromosome GGA Zp (8,942,878 - 11,608,187)

Clinical features: "Hemizygous female mutants (Z-/W) exhibit craniofacial defects along with truncation of the extremities, short stature, exposed viscera, preaxial polydactly, mild to severe cleft palate and a shortened upper beak; occasional elongation and duplication of the fibula" (Robb et al., 2011)

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2011 Robb, EA., Gitter, CL., Cheng, HH., Delany, ME. :
Chromosomal mapping and candidate gene discovery of chicken developmental mutants and genome-wide variation analysis of MHC congenics. J Hered 102:141-56, 2011. Pubmed reference: 21273214. DOI: 10.1093/jhered/esq122.
1996 Rodriguez, C., Kos, R., Macias, D., Abbott, U.K., Belmonte, J.C.I. :
Shh, hoxd, BMP-2, and FGF-4 gene expression during development of the polydactylous Talpid(2), Diplopodia(1), and Diplopodia(4) mutant chick limb buds Developmental Genetics 19:26-32, 1996. Pubmed reference: 8792606. DOI: 10.1002/(SICI)1520-6408(1996)19:1<26::AID-DVG3>3.0.CO;2-2.
1975 MacCabe, JA., MacCabe, AB., Abbott, UK., McCarrey, JR. :
Limb development in diplopodia4: a polydactylous mutation in the chicken. J Exp Zool 191:383-94, 1975. Pubmed reference: 1127402. DOI: 10.1002/jez.1401910309.

Edit History


  • Created by Frank Nicholas on 25 Feb 2011
  • Changed by Frank Nicholas on 17 Oct 2011