OMIA 001323-9823 : Dwarfism, Laron in Sus scrofa

In other species: cattle

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 262500 (trait) , 604271 (trait) , 600946 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Genetically-modifed organism; GMO

Molecular basis: Cui et al. (2015) created a GMO miniature pig model of Laron disease by knocking out the GHR gene via zinc finger nucleas (ZFN technology.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GHR growth hormone receptor Sus scrofa 16 NC_010458.4 (27126300..27422618) GHR Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Zhu, X.X., Pan, J.S., Lin, T., Yang, Y.C., Huang, Q.Y., Yang, S.P., Qu, Z.X., Lin, Z.S., Wen, J.C., Yan, A.F., Feng, J., Liu, L., Zhang, X.L., Lu, J.H., Tang, D.S. :
Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells. Biotechnol Lett :, 2022. Pubmed reference: 34997407. DOI: 10.1007/s10529-021-03214-x.
2021 Han, Q., Chen, H., Wang, L., An, Y., Hu, X., Zhao, Y., Zhang, H., Zhang, R. :
Systemic deficiency of GHR in pigs leads to hepatic steatosis via negative regulation of AHR signaling. Int J Biol Sci 17:4108-4121, 2021. Pubmed reference: 34803486. DOI: 10.7150/ijbs.64894.
2018 Yu, H., Long, W., Zhang, X., Xu, K., Guo, J., Zhao, H., Li, H., Qing, Y., Pan, W., Jia, B., Zhao, H.Y., Huang, X., Wei, H.J. :
Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. J Transl Med 16:41, 2018. Pubmed reference: 29482569. DOI: 10.1186/s12967-018-1409-7.
2015 Cui, D., Li, F., Li, Q., Li, J., Zhao, Y., Hu, X., Zhang, R., Li, N. :
Generation of a miniature pig disease model for human Laron syndrome. Sci Rep 5:15603, 2015. Pubmed reference: 26511035. DOI: 10.1038/srep15603.

Edit History


  • Created by Frank Nicholas on 29 Sep 2016
  • Changed by Frank Nicholas on 29 Sep 2016
  • Changed by Imke Tammen2 on 27 Aug 2021
  • Changed by Imke Tammen2 on 24 Nov 2021
  • Changed by Imke Tammen2 on 30 Jan 2022