OMIA:001356-9913 : Coat colour, grey/gray in Bos taurus (taurine cattle)
Categories: Pigmentation phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 604204 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Species-specific description: Senczuk et al. (2020): " Worldwide, several breeds share peculiar coat color features such as the presence of a fawn pigmentation of the calf at birth, turning over time to grey, and sexual dichromatism."
Molecular basis: Senczuk et al. (2020) studied "fifteen grey cattle breeds (Chianina, Corsa, Croatian Podolian, Garfagnina, Gascon, Guelmoise, Hungarian Grey, Italian Podolian, Marchigiana, Maremmana, Piedmontese, Romagnola, Turkish Grey, Tyrolean Grey, and Ukrainian Grey) and four “non-grey” cattle breeds (Angus, Charolais, Limousin, and Holstein)." They concluded that "Many of the candidate genes detected in differentially selected regions had pleiotropic effects, and altogether they were implicated in all of the three principal stages in pigmentation, i.e., melanocyte development, melanogenesis, and pigment trafficking/transfer, highlighting the complex nature of the grey phenotype in cattle. We cannot exclude that the putative selection signatures detected in this study may have captured general differences in the overall architecture and functioning of skin and skin appendages between grey cattle breeds and the reference breeds in addition to more specific differences in coat patterning and pigmentation, which was our specific goal."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2020||Senczuk, G., Guerra, L., Mastrangelo, S., Campobasso, C., Zoubeyda, K., Imane, M., Marletta, D., Kusza, S., Karsli, T., Gaouar, S.B.S., Pilla, F., Ciani, E. :|
|Fifteen Shades of Grey: Combined Analysis of Genome-Wide SNP Data in Steppe and Mediterranean Grey Cattle Sheds New Light on the Molecular Basis of Coat Color. Genes (Basel) 11, 2020. Pubmed reference: 32823527. DOI: 10.3390/genes11080932.|
- Created by Frank Nicholas on 01 Sep 2020
- Changed by Frank Nicholas on 01 Sep 2020