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OMIA:001404-9823 : Leptin concentration in Sus scrofa (pig)

In other species: taurine cattle , rabbit

Categories: Homeostasis / metabolism phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 164160 (gene) , 614962 (trait) , 601007 (gene) , 614963 (trait)

Mendelian trait/disorder: yes

Disease-related: no

Key variant known: no

Molecular basis: Chen et al. (2018) used somatic cell nuclear transfer technique to create transgenic leptin pigs controlled by the pig leptin (pleptin) promoter to overexpress leptin.
Tan et al. (2023) used ZFN vectors to generate leptin-deficient (Leptin-/-) pigs as a model for non-alcoholic fatty liver disease in humans. This study involves genetically modified organisms (GMO).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001404-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Jamal, M.A., Cheng, Y., Jiao, D., Cheng, W., Zou, D., Wang, X., Wei, T., Guo, J., Xu, K., Zhao, H., Pu, S., Yang, C., Qing, Y., Jia, B., Li, H., Zhao, R., Zhao, H.Y., Wei, H.J. :
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model. Biol Res 57:60, 2024. Pubmed reference: 39227998. DOI: 10.1186/s40659-024-00545-7.
2023 Suárez-Mesa, R., Ros-Freixedes, R., Díaz, M., Marsellés, J., Pena, R.N., Reixach, J., Estany, J. :
The leptin receptor gene affects piglet behavior and growth. J Anim Sci 101:skad296, 2023. Pubmed reference: 37659087. DOI: 10.1093/jas/skad296.
Tan, T., Song, Z., Li, W., Wang, R., Zhu, M., Liang, Z., Bai, Y., Wang, Q., Wu, H., Hu, X., Xing, Y. :
Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis. Cell Biosci 13:169, 2023. Pubmed reference: 37705071. DOI: 10.1186/s13578-023-01124-1.
2022 Qing, Y., Jamal, M.A., Shi, D., Zhao, S., Xu, K., Jiao, D., Zhao, H., Li, H., Jia, B., Wang, H., Zhao, H.Y., Wei, H.J. :
Delayed body development with reduced triglycerides levels in leptin transgenic pigs. Transgenic Res 31:59-72, 2022. Pubmed reference: 34741281. DOI: 10.1007/s11248-021-00288-1.
2021 Solé, E., Ros-Freixedes, R., Tor, M., Reixach, J., Pena, R.N., Estany, J. :
Antagonistic maternal and direct effects of the leptin receptor gene on body weight in pigs. PLoS One 16:e0246198, 2021. Pubmed reference: 33508034. DOI: 10.1371/journal.pone.0246198.
2018 Chen, J., Zeng, W., Pan, W., Peng, C., Zhang, J., Su, J., Long, W., Zhao, H., Zuo, X., Xie, X., Wu, J., Nie, L., Zhao, H.Y., Wei, H.J., Chen, X. :
Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs. PLoS Biol 16:e2005354, 2018. Pubmed reference: 30169503. DOI: 10.1371/journal.pbio.2005354.
2016 Ros-Freixedes, R., Gol, S., Pena, R.N., Tor, M., Ibáñez-Escriche, N., Dekkers, J.C., Estany, J. :
Genome-wide association study singles out SCD and LEPR as the two main loci influencing intramuscular fat content and fatty acid composition in Duroc pigs. PLoS One 11:e0152496, 2016. Pubmed reference: 27023885. DOI: 10.1371/journal.pone.0152496.
2010 Ovilo, C., Fernández, A., Fernández, A.I., Folch, J.M., Varona, L., Benítez, R., Nuñez, Y., Rodríguez, C., Silió, L. :
Hypothalamic expression of porcine leptin receptor (LEPR), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript (CART) genes is influenced by LEPR genotype. Mamm Genome 21:583-91, 2010. Pubmed reference: 21128076. DOI: 10.1007/s00335-010-9307-1.
2005 Ovilo, C., Fernández, A., Noguera, J.L., Barragán, C., Letón, R., Rodríguez, C., Mercadé, A., Alves, E., Folch, J.M., Varona, L., Toro, M. :
Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross. Genet Res 85:57-67, 2005. Pubmed reference: 16089036. DOI: 10.1017/s0016672305007330.

Edit History


  • Created by Imke Tammen2 on 04 Sep 2023
  • Changed by Imke Tammen2 on 04 Sep 2023
  • Changed by Imke Tammen2 on 17 Sep 2023
  • Changed by Imke Tammen2 on 15 Oct 2023
  • Changed by Imke Tammen2 on 05 Sep 2024