OMIA:001404-9823 : Leptin concentration in Sus scrofa (pig)

In other species: taurine cattle

Categories: Homeostasis / metabolism phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Molecular basis: Tan et al. (2023) used ZFN vectors to generate leptin-deficient (Leptin-/-) pigs as a model for non-alcoholic fatty liver disease in humans. This study involves genetically modified organisms (GMO).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001404-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Suárez-Mesa, R., Ros-Freixedes, R., Díaz, M., Marsellés, J., Pena, R.N., Reixach, J., Estany, J. :
The leptin receptor gene affects piglet behavior and growth. J Anim Sci , 2023. Pubmed reference: 37659087. DOI: 10.1093/jas/skad296.
Tan, T., Song, Z., Li, W., Wang, R., Zhu, M., Liang, Z., Bai, Y., Wang, Q., Wu, H., Hu, X., Xing, Y. :
Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis. Cell Biosci 13:169, 2023. Pubmed reference: 37705071. DOI: 10.1186/s13578-023-01124-1.
2021 Solé, E., Ros-Freixedes, R., Tor, M., Reixach, J., Pena, R.N., Estany, J. :
Antagonistic maternal and direct effects of the leptin receptor gene on body weight in pigs. PLoS One 16:e0246198, 2021. Pubmed reference: 33508034. DOI: 10.1371/journal.pone.0246198.
2016 Ros-Freixedes, R., Gol, S., Pena, R.N., Tor, M., Ibáñez-Escriche, N., Dekkers, J.C., Estany, J. :
Genome-wide association study singles out SCD and LEPR as the two main loci influencing intramuscular fat content and fatty acid composition in Duroc pigs. PLoS One 11:e0152496, 2016. Pubmed reference: 27023885. DOI: 10.1371/journal.pone.0152496.
2010 Ovilo, C., Fernández, A., Fernández, A.I., Folch, J.M., Varona, L., Benítez, R., Nuñez, Y., Rodríguez, C., Silió, L. :
Hypothalamic expression of porcine leptin receptor (LEPR), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript (CART) genes is influenced by LEPR genotype. Mamm Genome 21:583-91, 2010. Pubmed reference: 21128076. DOI: 10.1007/s00335-010-9307-1.
2005 Ovilo, C., Fernández, A., Noguera, J.L., Barragán, C., Letón, R., Rodríguez, C., Mercadé, A., Alves, E., Folch, J.M., Varona, L., Toro, M. :
Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross. Genet Res 85:57-67, 2005. Pubmed reference: 16089036. DOI: 10.1017/s0016672305007330.

Edit History

  • Created by Imke Tammen2 on 04 Sep 2023
  • Changed by Imke Tammen2 on 04 Sep 2023
  • Changed by Imke Tammen2 on 17 Sep 2023
  • Changed by Imke Tammen2 on 15 Oct 2023