OMIA:001404-9823 : Leptin concentration in Sus scrofa (pig) |
In other species: taurine cattle , rabbit
Categories: Homeostasis / metabolism phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 164160 (gene) , 614962 (trait) , 601007 (gene) , 614963 (trait)
Single-gene trait/disorder: yes
Disease-related: no
Key variant known: no
Molecular basis:
Chen et al. (2018) used somatic cell nuclear transfer technique to create transgenic leptin pigs controlled by the pig leptin (pleptin) promoter to overexpress leptin.
Tan et al. (2023) used ZFN vectors to generate leptin-deficient (Leptin-/-) pigs as a model for non-alcoholic fatty liver disease in humans. This study involves genetically modified organisms (GMO).
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001404-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2024 | Jamal, M.A., Cheng, Y., Jiao, D., Cheng, W., Zou, D., Wang, X., Wei, T., Guo, J., Xu, K., Zhao, H., Pu, S., Yang, C., Qing, Y., Jia, B., Li, H., Zhao, R., Zhao, H.Y., Wei, H.J. : |
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model. Biol Res 57:60, 2024. Pubmed reference: 39227998. DOI: 10.1186/s40659-024-00545-7. | |
2023 | Suárez-Mesa, R., Ros-Freixedes, R., Díaz, M., Marsellés, J., Pena, R.N., Reixach, J., Estany, J. : |
The leptin receptor gene affects piglet behavior and growth. J Anim Sci 101:skad296, 2023. Pubmed reference: 37659087. DOI: 10.1093/jas/skad296. | |
Tan, T., Song, Z., Li, W., Wang, R., Zhu, M., Liang, Z., Bai, Y., Wang, Q., Wu, H., Hu, X., Xing, Y. : | |
Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis. Cell Biosci 13:169, 2023. Pubmed reference: 37705071. DOI: 10.1186/s13578-023-01124-1. | |
2022 | Qing, Y., Jamal, M.A., Shi, D., Zhao, S., Xu, K., Jiao, D., Zhao, H., Li, H., Jia, B., Wang, H., Zhao, H.Y., Wei, H.J. : |
Delayed body development with reduced triglycerides levels in leptin transgenic pigs. Transgenic Res 31:59-72, 2022. Pubmed reference: 34741281. DOI: 10.1007/s11248-021-00288-1. | |
2021 | Solé, E., Ros-Freixedes, R., Tor, M., Reixach, J., Pena, R.N., Estany, J. : |
Antagonistic maternal and direct effects of the leptin receptor gene on body weight in pigs. PLoS One 16:e0246198, 2021. Pubmed reference: 33508034. DOI: 10.1371/journal.pone.0246198. | |
2018 | Chen, J., Zeng, W., Pan, W., Peng, C., Zhang, J., Su, J., Long, W., Zhao, H., Zuo, X., Xie, X., Wu, J., Nie, L., Zhao, H.Y., Wei, H.J., Chen, X. : |
Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs. PLoS Biol 16:e2005354, 2018. Pubmed reference: 30169503. DOI: 10.1371/journal.pbio.2005354. | |
2016 | Ros-Freixedes, R., Gol, S., Pena, R.N., Tor, M., Ibáñez-Escriche, N., Dekkers, J.C., Estany, J. : |
Genome-wide association study singles out SCD and LEPR as the two main loci influencing intramuscular fat content and fatty acid composition in Duroc pigs. PLoS One 11:e0152496, 2016. Pubmed reference: 27023885. DOI: 10.1371/journal.pone.0152496. | |
2010 | Ovilo, C., Fernández, A., Fernández, A.I., Folch, J.M., Varona, L., Benítez, R., Nuñez, Y., Rodríguez, C., Silió, L. : |
Hypothalamic expression of porcine leptin receptor (LEPR), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript (CART) genes is influenced by LEPR genotype. Mamm Genome 21:583-91, 2010. Pubmed reference: 21128076. DOI: 10.1007/s00335-010-9307-1. | |
2005 | Ovilo, C., Fernández, A., Noguera, J.L., Barragán, C., Letón, R., Rodríguez, C., Mercadé, A., Alves, E., Folch, J.M., Varona, L., Toro, M. : |
Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross. Genet Res 85:57-67, 2005. Pubmed reference: 16089036. DOI: 10.1017/s0016672305007330. |
Edit History
- Created by Imke Tammen2 on 04 Sep 2023
- Changed by Imke Tammen2 on 04 Sep 2023
- Changed by Imke Tammen2 on 17 Sep 2023
- Changed by Imke Tammen2 on 15 Oct 2023
- Changed by Imke Tammen2 on 05 Sep 2024