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OMIA 001416-9612 : Coat colour, dominant black in Canis lupus

In other species: dog , coyote , water buffalo

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2009

Cross-species summary: Also known as the K locus

Molecular basis: Anderson et a. (2009) showed that the 3bp deletion of the CBD103 gene that causes dominant black in dogs, exists also in the orthologous gene in wolves and coyotes, and is strongly associated with black coat colour in both these species.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CBD103 Canis lupus - no genomic information (-..-) CBD103 Ensembl

Variants

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Coat colour, dominant black CBD103 deletion, small (<=20) 3bp deletion of the CBD103 gene 2009 19197024
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Reference


2009 Anderson, TM., Vonholdt, BM., Candille, SI., Musiani, M., Greco, C., Stahler, DR., Smith, DW., Padhukasahasram, B., Randi, E., Leonard, JA., Bustamante, CD., Ostrander, EA., Tang, H., Wayne, RK., Barsh, GS. :
Molecular and evolutionary history of melanism in North American gray wolves. Science 323:1339-43, 2009. Pubmed reference: 19197024. DOI: 10.1126/science.1165448.

Edit History


  • Created by Frank Nicholas on 12 Oct 2011
  • Changed by Frank Nicholas on 12 Oct 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Frank Nicholas on 21 Mar 2012