OMIA:001417-9685 : Pulmonary fibrosis, idiopathic in Felis catus (domestic cat)
In other species: dog
Categories: Respiratory system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 178500 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific symbol: IPF
Species-specific description: The paper by Williams et al. (2004) is the first report of an animal model of human idiopathic pulmonary fibrosis.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Pathology: As reported by Williams et al. (2004), the histopathology comprises "(1) interstitial fibrosis with fibroblast/myofibroblast foci, (2) honeycombing with alveolar epithelial metaplasia and type II pneumocyte hyperplasia, and (3) alveolar interstitial smooth-muscle metaplasia. Interstitial inflammation was not a prominent feature of the disease. alpha-Smooth muscle actin-positive myofibroblasts were prominent in myofibroblast foci, beneath honeycomb and hyperplastic epithelium, and in alveolar septa away from the remodeling. Feline IPF type II pneumocyte ultrastructure is similar to a heritable form of human IPF, with abnormal cytoplasmic lamellar body-like inclusions. "
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2013||Evola, M.G., Edmondson, E.F., Reichle, J.K., Biller, D.S., Mitchell, C.W., Valdés-Martínez, A. :|
|Radiographic and histopathologic characteristics of pulmonary fibrosis in nine cats. Vet Radiol Ultrasound , 2013. Pubmed reference: 24103063. DOI: 10.1111/vru.12106.|
|2008||Secrest, S.A., Bailey, M.Q., Williams, K.J., Smarick, S.D. :|
|Imaging diagnosis--Feline idiopathic pulmonary fibrosis. Vet Radiol Ultrasound 49:47-50, 2008. Pubmed reference: 18251294.|
|2004||Cohn, L.A., Norris, C.R., Hawkins, E.C., Dye, J.A., Johnson, C.A., Williams, K.J. :|
|Identification and characterization of an idiopathic pulmonary fibrosis-like condition in cats. J Vet Intern Med 18:632-41, 2004. Pubmed reference: 15515577.|
|Williams, K., Malarkey, D., Cohn, L., Patrick, D., Dye, J., Toews, G. :|
|Identification of spontaneous feline idiopathic pulmonary fibrosis: morphology and ultrastructural evidence for a type II pneumocyte defect. Chest 125:2278-88, 2004. Pubmed reference: 15189952.|
- Created by Frank Nicholas on 06 Oct 2005