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OMIA:001417-9685 : Pulmonary fibrosis, idiopathic in Felis catus (domestic cat)

In other species: dog

Categories: Respiratory system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 178500 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific symbol: IPF

Species-specific description: The paper by Williams et al. (2004) is the first report of an animal model of human idiopathic pulmonary fibrosis.

Pathology: As reported by Williams et al. (2004), the histopathology comprises "(1) interstitial fibrosis with fibroblast/myofibroblast foci, (2) honeycombing with alveolar epithelial metaplasia and type II pneumocyte hyperplasia, and (3) alveolar interstitial smooth-muscle metaplasia. Interstitial inflammation was not a prominent feature of the disease. alpha-Smooth muscle actin-positive myofibroblasts were prominent in myofibroblast foci, beneath honeycomb and hyperplastic epithelium, and in alveolar septa away from the remodeling. Feline IPF type II pneumocyte ultrastructure is similar to a heritable form of human IPF, with abnormal cytoplasmic lamellar body-like inclusions. "

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:001417-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2013 Evola, M.G., Edmondson, E.F., Reichle, J.K., Biller, D.S., Mitchell, C.W., Valdés-Martínez, A. :
Radiographic and histopathologic characteristics of pulmonary fibrosis in nine cats. Vet Radiol Ultrasound 55:133-40, 2013. Pubmed reference: 24103063. DOI: 10.1111/vru.12106.
2008 Secrest, S.A., Bailey, M.Q., Williams, K.J., Smarick, S.D. :
Imaging diagnosis--Feline idiopathic pulmonary fibrosis. Vet Radiol Ultrasound 49:47-50, 2008. Pubmed reference: 18251294. DOI: 10.1111/j.1740-8261.2007.00316.x.
2004 Cohn, L.A., Norris, C.R., Hawkins, E.C., Dye, J.A., Johnson, C.A., Williams, K.J. :
Identification and characterization of an idiopathic pulmonary fibrosis-like condition in cats. J Vet Intern Med 18:632-41, 2004. Pubmed reference: 15515577. DOI: 10.1892/0891-6640(2004)18<632:iacoai>2.0.co;2.
Williams, K., Malarkey, D., Cohn, L., Patrick, D., Dye, J., Toews, G. :
Identification of spontaneous feline idiopathic pulmonary fibrosis: morphology and ultrastructural evidence for a type II pneumocyte defect. Chest 125:2278-88, 2004. Pubmed reference: 15189952. DOI: 10.1378/chest.125.6.2278.

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  • Created by Frank Nicholas on 06 Oct 2005