OMIA 001436-9823 : Non-shivering thermiogenesis, absence of in Sus scrofa
Zheng et al. (2017) report the "application of a CRISPR/Cas9-mediated, homologous recombination (HR)-independent approach to efficiently insert mouse adiponectin-UCP1 into the porcine endogenous UCP1 locus." (GMO)Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|UCP1||uncoupling protein 1||Sus scrofa||-||no genomic information (-..-)||UCP1||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|931||Non-shivering thermiogenesis, absence of||UCP1||deletion, gross (>20)||Naturally occurring variant||8||"exons 3 to 5 were eliminated by a deletion in the pig sequence"||2006||16933999|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2022||Tu, C.F., Chuang, C.K., Yang, T.S. :|
|The application of new breeding technology based on gene editing in pig industry. Anim Biosci :, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.|
|2017||Hou, L., Shi, J., Cao, L., Xu, G., Hu, C., Wang, C. :|
|Pig has no uncoupling protein 1. Biochem Biophys Res Commun 487:795-800, 2017. Pubmed reference: 28442343. DOI: 10.1016/j.bbrc.2017.04.118.|
|Lin, J., Cao, C., Tao, C., Ye, R., Dong, M., Zheng, Q., Wang, C., Jiang, X., Qin, G., Yan, C., Li, K., Speakman, J.R., Wang, Y., Jin, W., Zhao, J. :|
|Cold adaptation in pigs depends on UCP3 in beige adipocytes. J Mol Cell Biol 9:364-375, 2017. Pubmed reference: 28486585. DOI: 10.1093/jmcb/mjx018.|
|Zheng, Q., Lin, J., Huang, J., Zhang, H., Zhang, R., Zhang, X., Cao, C., Hambly, C., Qin, G., Yao, J., Song, R., Jia, Q., Wang, X., Li, Y., Zhang, N., Piao, Z., Ye, R., Speakman, J.R., Wang, H., Zhou, Q., Wang, Y., Jin, W., Zhao, J. :|
|UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. Proc Natl Acad Sci U S A 114:E9474-E9482, 2017. Pubmed reference: 29078316. DOI: 10.1073/pnas.1707853114.|
|2006||Berg, F., Gustafson, U., Andersson, L. :|
|The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: A genetic explanation for poor thermoregulation in piglets. PLoS Genet 2:e129, 2006. Pubmed reference: 16933999. DOI: 10.1371/journal.pgen.0020129.|
|1989||Trayhurn, P., Temple, N.J., Van Aerde, J. :|
|Evidence from immunoblotting studies on uncoupling protein that brown adipose tissue is not present in the domestic pig. Can J Physiol Pharmacol 67:1480-5, 1989. Pubmed reference: 2627687. DOI: 10.1139/y89-239.|
- Created by Frank Nicholas on 01 Dec 2009
- Changed by Frank Nicholas on 08 Oct 2011
- Changed by Frank Nicholas on 09 Dec 2011
- Changed by Frank Nicholas on 05 Aug 2013
- Changed by Frank Nicholas on 12 Dec 2017
- Changed by Imke Tammen2 on 25 Jun 2021
- Changed by Imke Tammen2 on 11 Jan 2022