OMIA 001441-9615 : Osteosarcoma in Canis lupus familiaris

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: yes

Key variant known: no

Species-specific symbol: OSA


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Jarvis, S., Koumadoraki, E., Madouros, N., Sharif, S., Saleem, A., Khan, S. :
Non-rodent animal models of osteosarcoma: A review. Cancer Treat Res Commun 27:100307, 2021. Pubmed reference: 33453605. DOI: 10.1016/j.ctarc.2021.100307.
2019 Makielski, K.M., Mills, L.J., Sarver, A.L., Henson, M.S., Spector, L.G., Naik, S., Modiano, J.F. :
Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review. Vet Sci 6:, 2019. Pubmed reference: 31130627. DOI: 10.3390/vetsci6020048.
2018 Sakthikumar, S., Elvers, I., Kim, J., Arendt, M.L., Thomas, R., Turner-Maier, J., Swofford, R., Johnson, J., Schumacher, S.E., Alföldi, J., Axelsson, E., Couto, C.G., Kisseberth, W.C., Pettersson, M.E., Getz, G., Meadows, J.R.S., Modiano, J.F., Breen, M., Kierczak, M., Forsberg-Nilsson, K., Marinescu, V.D., Lindblad-Toh, K. :
<i>SETD2</i> Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma. Cancer Res 78:3421-3431, 2018. Pubmed reference: 29724721. DOI: 10.1158/0008-5472.CAN-17-3558.
Shao, Y.W., Wood, G.A., Lu, J., Tang, Q.L., Liu, J., Molyneux, S., Chen, Y., Fang, H., Adissu, H., McKee, T., Waterhouse, P., Khokha, R. :
Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene :, 2018. Pubmed reference: 30093633. DOI: 10.1038/s41388-018-0444-4.
2017 Sapierzyński, R., Czopowicz, M. :
The animal-dependent risk factors in canine osteosarcomas. Pol J Vet Sci 20:293-298, 2017. Pubmed reference: 28865206. DOI: 10.1515/pjvs-2017-0035.
2014 Davis, B.W., Ostrander, E.A. :
Domestic dogs and cancer research: a breed-based genomics approach. ILAR J 55:59-68, 2014. Pubmed reference: 24936030. DOI: 10.1093/ilar/ilu017.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
Karlsson, E.K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., Howald, C., Tonomura, N., Perloski, M., Swofford, R., Biagi, T., Fryc, S., Anderson, N., Courtay-Cahen, C., Youell, L., Ricketts, S.L., Mandlebaum, S., Rivera, P., von Euler, H., Kisseberth, W.C., London, C.A., Lander, E.S., Couto, G., Comstock, K., Starkey, M.P., Modiano, J.F., Breen, M., Lindblad-Toh, K. :
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol 14:R132, 2013. Pubmed reference: 24330828. DOI: 10.1186/gb-2013-14-12-r132.
2012 Tsai, P.C., Breen, M. :
Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs. Am J Vet Res 73:1335-43, 2012. Pubmed reference: 22924713. DOI: 10.2460/ajvr.73.9.1335.
2010 Morello, E., Martano, M., Buracco, P. :
Biology, diagnosis and treatment of canine appendicular osteosarcoma: Similarities and differences with human osteosarcoma. Vet J :, 2010. Pubmed reference: 20889358. DOI: 10.1016/j.tvjl.2010.08.014.
O'Donoghue, LE., Ptitsyn, AA., Kamstock, DA., Siebert, J., Thomas, RS., Duval, DL. :
Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome. BMC Cancer 10:506, 2010. Pubmed reference: 20860831. DOI: 10.1186/1471-2407-10-506.
Phillips, JC., Lembcke, L., Chamberlin, T. :
A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26. Genomics 96:220-7, 2010. Pubmed reference: 20647041. DOI: 10.1016/j.ygeno.2010.07.002.
Rissetto, KC., Rindt, H., Selting, KA., Villamil, JA., Henry, CJ., Reinero, CR. :
Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma. Vet Immunol Immunopathol 135:137-45, 2010. Pubmed reference: 20197202. DOI: 10.1016/j.vetimm.2010.02.002.
Selvarajah, GT., Kirpensteijn, J. :
Prognostic and predictive biomarkers of canine osteosarcoma. Vet J 185:28-35, 2010. Pubmed reference: 20493743. DOI: 10.1016/j.tvjl.2010.04.010.
Sottnik, JL., Rao, S., Lafferty, MH., Thamm, DH., Morley, PS., Withrow, SJ., Dow, SW. :
Association of Blood Monocyte and Lymphocyte Count and Disease-Free Interval in Dogs with Osteosarcoma. J Vet Intern Med :, 2010. Pubmed reference: 20840314. DOI: 10.1111/j.1939-1676.2010.0591.x.
2009 Fossey, SL., Liao, AT., McCleese, JK., Bear, MD., Lin, J., Li, PK., Kisseberth, WC., London, CA. :
Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer 9:81, 2009. Pubmed reference: 7704483. DOI: 10.3109/10611869408996814.
Selvarajah, GT., Kirpensteijn, J., van Wolferen, ME., Rao, NA., Fieten, H., Mol, JA. :
Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Mol Cancer 8:72, 2009. Pubmed reference: 14761893. DOI: 10.1152/ajpcell.00407.2003.
Thomas, R., Wang, HJ., Tsai, PC., Langford, CF., Fosmire, SP., Jubala, CM., Getzy, DM., Cutter, GR., Modiano, JF., Breen, M. :
Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Res 17:365-77, 2009. Pubmed reference: 19337847. DOI: 10.1007/s10577-009-9028-z.
2008 Kirpensteijn, J., Kik, M., Teske, E., Rutteman, GR. :
TP53 gene mutations in canine osteosarcoma. Vet Surg 37:454-60, 2008. Pubmed reference: 18986312. DOI: 10.1111/j.1532-950X.2008.00407.x.
2007 Phillips, JC., Stephenson, B., Hauck, M., Dillberger, J. :
Heritability and segregation analysis of osteosarcoma in the Scottish deerhound. Genomics 90:354-63, 2007. Pubmed reference: 17628392. DOI: 10.1016/j.ygeno.2007.05.001.
2006 Khanna, C., Lindblad-Toh, K., Vail, D., London, C., Bergman, P., Barber, L., Breen, M., Kitchell, B., McNeil, E., Modiano, JF., Niemi, S., Comstock, KE., Ostrander, E., Westmoreland, S., Withrow, S. :
The dog as a cancer model. Nat Biotechnol 24:1065-6, 2006. Pubmed reference: 16964204. DOI: 10.1038/nbt0906-1065b.
2005 Dow, S., Elmslie, R., Kurzman, I., MacEwen, G., Pericle, F., Liggitt, D. :
Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases. Hum Gene Ther 16:937-46, 2005. Pubmed reference: 16076252. DOI: 10.1089/hum.2005.16.937.
Mullins, MN., Lana, SE., Dernell, WS., Ogilvie, GK., Withrow, SJ., Ehrhart, EJ. :
Cyclooxygenase-2 expression in canine appendicular osteosarcomas. J Vet Intern Med 18:859-65, 2005. Pubmed reference: 15638270.
2004 Flint, AF., U'Ren, L., Legare, ME., Withrow, SJ., Dernell, W., Hanneman, WH. :
Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. Vet Pathol 41:291-6, 2004. Pubmed reference: 15133183. DOI: 10.1354/vp.41-3-291.
Khanna, C., Wan, X., Bose, S., Cassaday, R., Olomu, O., Mendoza, A., Yeung, C., Gorlick, R., Hewitt, SM., Helman, LJ. :
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 10:182-6, 2004. Pubmed reference: 14704791. DOI: 10.1038/nm982.
2003 MacEwen, EG., Kutzke, J., Carew, J., Pastor, J., Schmidt, JA., Tsan, R., Thamm, DH., Radinsky, R. :
c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin Exp Metastasis 20:421-30, 2003. Pubmed reference: 14524531.
2002 Levine, RA. :
Overexpression of the sis oncogene in a canine osteosarcoma cell line. Vet Pathol 39:411-2, 2002. Pubmed reference: 12014510.
Levine, RA., Forest, T., Smith, C. :
Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors. Vet Pathol 39:372-8, 2002. Pubmed reference: 12014501.
2000 Ferracini, R., Angelini, P., Cagliero, E., Linari, A., Martano, M., Wunder, J., Buracco, P. :
MET oncogene aberrant expression in canine osteosarcoma. J Orthop Res 18:253-6, 2000. Pubmed reference: 10815826. DOI: 10.1002/jor.1100180213.
1999 Mendoza, S., Konishi, T., Dernell, WS., Withrow, SJ., Miller, CW. :
Status of the p53, Rb and MDM2 genes in canine osteosarcoma. Anticancer Res 18:4449-53, 1999. Pubmed reference: 9891508.
1998 Johnson, AS., Couto, CG., Weghorst, CM. :
Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog. Carcinogenesis 19:213-7, 1998. Pubmed reference: 9472714.
Ru, G., Terracini, B., Glickman, LT. :
Host related risk factors for canine osteosarcoma. Vet J 156:31-9, 1998. Pubmed reference: 9691849.
1997 van Leeuwen, IS., Cornelisse, CJ., Misdorp, W., Goedegebuure, SA., Kirpensteijn, J., Rutteman, GR. :
P53 gene mutations in osteosarcomas in the dog. Cancer Lett 111:173-8, 1997. Pubmed reference: 9022143.
1996 Sagartz, JE., Bodley, WL., Gamblin, RM., Couto, CG., Tierney, LA., Capen, CC. :
p53 tumor suppressor protein overexpression in osteogenic tumors of dogs. Vet Pathol 33:213-21, 1996. Pubmed reference: 8801715.

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  • Created by Frank Nicholas on 02 Nov 2010