OMIA 001465-9823 : Arthrogryposis multiplex congenita, generic in Sus scrofa

In other species: cattle , sheep

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: no

Species-specific description: Can be caused by various non-genetic factors such as ingestion of Jimsonweed or tobacco by pregnant sows. However, there is convincing evidence of a single-locus autosomal recessive form of this disorder (Lomo, 1985).

Inheritance: Lomo (1985) provided convincing evidence of a single-locus autosomal recessive form of this disorder.

Mapping: Genini et al. (2004) mapped porcine AMC to SSC5 q12-q23, at 92cM on a linkage map. Haubitz et al. (2012) refined the location to a 2.32 Mb region of SSC5.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2012 Haubitz, M., Neuenschwander, S., Vögeli, P. :
Porcine arthrogryposis multiplex congenita (AMC): New diagnostic test and narrowed candidate region. Mol Cell Probes 26:248-52, 2012. Pubmed reference: 22405934. DOI: 10.1016/j.mcp.2012.02.005.
2006 Genini, S., Nguyen, T.T., Malek, M., Talbot, R., Gebert, S., Rohrer, G., Nonneman, D., Stranzinger, G., Vögeli, P. :
Radiation hybrid mapping of 18 positional and physiological candidate genes for arthrogryposis multiplex congenita on porcine chromosome 5. Anim Genet 37:239-44, 2006. Pubmed reference: 16734683. DOI: 10.1111/j.1365-2052.2006.01447.x.
2004 Genini, S., Malek, M., Spilar, S., Nguyen, T.T., Ménétrey, F., Gebert, S., Hagger, C., Neuenschwander, S., Kadarmideen, H.N., Stranzinger, G., Vögeli, P. :
Arthrogryposis multiplex congenita (AMC), a hereditary disease in swine, maps to chromosome 5 by linkage analysis. Mamm Genome 15:935-41, 2004. Pubmed reference: 15672597.
1986 Hajkova, J., Cerny, M., Borkovec, L., Lojda, L. :
[Screening for genetic health and the intensification of production of pig meat] Veterinarstvi 36:348-351, 1986.
1985 Lomo, O.M. :
Arthrogryposis and associated defects in pigs: indication of simple recessive inheritance Acta Veterinaria Scandinavica 26:419-422, 1985. Pubmed reference: 4096326.
1979 Ely, R., Leipold, H.W. :
Arthrogryposis in Yorkshire piglets Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 96:241-252, 1979.
1974 Swatland, H.J. :
Developmental disorders of skeletal muscle in cattle, pigs and sheep Veterinary Bulletin 44:179-200, 1974.
1973 Crowe, M.W., Pike, H.T. :
Congenital arthrogryposis associated with ingestion of tobacco stalks by pregnant sows Journal of the American Veterinary Medical Association 162:453-455, 1973. Pubmed reference: 4692297.
Leipold, H.W., Oehme, F.W., Cook, J.E. :
Congenital arthrogryposis associated with ingestion of Jimsonweed by pregnant sows Journal of the American Veterinary Medical Association 162:1059-1060, 1973. Pubmed reference: 4709616.
1933 Hallqvist, C. :
Ein Fall von letalfaktoren beim Schwein Hereditas 18:215-224, 1933.

Edit History


  • Created by Frank Nicholas on 18 Dec 2012
  • Changed by Frank Nicholas on 16 Jan 2013