OMIA 001470-9615 : Necrotizing meningoencephalitis in Canis lupus familiaris

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific symbol: NME

Mapping: By conducting a GWAS on 28 affected and 66 control Pugs, each genotyped with the Illumina CanineHD Genotyping BeadChip (yielding 86,692 informative SNPs for analysis), Barber et al. (2011) highlighted two regions, one being the DLA class-II region of the MHC on chromosome CFA12, and the other being within the STYX gene on CFA8.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2014 Cooper, J.J., Schatzberg, S.J., Vernau, K.M., Summers, B.A., Porter, B.F., Siso, S., Young, B.D., Levine, J.M. :
Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review. J Vet Intern Med 28:198-203, 2014. Pubmed reference: 24428322. DOI: 10.1111/jvim.12233.
2011 Barber, R.M., Schatzberg, S.J., Corneveaux, J.J., Allen, A.N., Porter, B.F., Pruzin, J.J., Platt, S.R., Kent, M., Huentelman, M.J. :
Identification of risk Loci for necrotizing meningoencephalitis in pug dogs. J Hered :S40-6, 2011. Pubmed reference: 21846746. DOI: 10.1093/jhered/esr048.
Pedersen, N., Liu, H., Millon, L., Greer, K. :
Dog leukocyte antigen class II-associated genetic risk testing for immune disorders of dogs: simplified approaches using Pug dog necrotizing meningoencephalitis as a model. J Vet Diagn Invest 23:68-76, 2011. Pubmed reference: 21217030.
Safra, N., Pedersen, NC., Wolf, Z., Johnson, EG., Liu, HW., Hughes, AM., Young, A., Bannasch, DL. :
Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations. Vet J :, 2011. Pubmed reference: 21741283. DOI: 10.1016/j.tvjl.2011.06.023.
2010 Greer, KA., Wong, AK., Liu, H., Famula, TR., Pedersen, NC., Ruhe, A., Wallace, M., Neff, MW. :
Necrotizing meningoencephalitis of Pug dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens 76:110-8, 2010. Pubmed reference: 20403140. DOI: 10.1111/j.1399-0039.2010.01484.x.
2009 Greer, KA., Schatzberg, SJ., Porter, BF., Jones, KA., Famula, TR., Murphy, KE. :
Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug. Res Vet Sci 86:438-42, 2009. Pubmed reference: 19014875. DOI: 10.1016/j.rvsc.2008.10.002.
Young, BD., Levine, JM., Fosgate, GT., de Lahunta, A., Flegel, T., Matiasek, K., Miller, A., Silver, G., Sharp, N., Greer, K., Schatzberg, SJ. :
Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in Pug dogs. J Vet Intern Med 23:527-35, 2009. Pubmed reference: 19645838. DOI: 10.1111/j.1939-1676.2009.0306.x.
2008 Eom, KD., Lim, CY., Gu, SH., Kang, BT., Kim, YB., Jang, DP., Woo, EJ., Kim, D., Cho, ZH., Park, HM. :
Positron emission tomography features of canine necrotizing meningoencephalitis. Vet Radiol Ultrasound 49:595-9, 2008. Pubmed reference: 19051653.
Higgins, RJ., Dickinson, PJ., Kube, SA., Moore, PF., Couto, SS., Vernau, KM., Sturges, BK., LeCouteur, RA. :
Necrotizing meningoencephalitis in five Chihuahua dogs. Vet Pathol 45:336-46, 2008. Pubmed reference: 18487490. DOI: 10.1354/vp.45-3-336.
Levine, JM., Fosgate, GT., Porter, B., Schatzberg, SJ., Greer, K. :
Epidemiology of necrotizing meningoencephalitis in Pug dogs. J Vet Intern Med 22:961-8, 2008. Pubmed reference: 18647157. DOI: 10.1111/j.1939-1676.2008.0137.x.
2004 Fearnside, SM., Kessell, AE., Powe, JR. :
Cervical hyperaesthesia in a Maltese Terrier with necrotising meningoencephalitis. Aust Vet J 82:550-2, 2004. Pubmed reference: 15478726.
1999 Ducoté, J.M., Johnson, K.E., Dewey, C.W., Walker, M.A., Coates, J.R., Berridge, B.R. :
Computed tomography of necrotizing meningoencephalitis in 3 Yorkshire Terriers. Vet Radiol Ultrasound 40:617-21, 1999. Pubmed reference: 10608689.
1995 Stalis, IH., Chadwick, B., Dayrell-Hart, B., Summers, BA., Van Winkle, TJ. :
Necrotizing meningoencephalitis of Maltese dogs. Vet Pathol 32:230-5, 1995. Pubmed reference: 7604489.
1994 Kobayashi, Y., Ochiai, K., Umemura, T., Goto, N., Ishida, T., Itakura, C. :
Necrotizing meningoencephalitis in pug dogs in Japan. J Comp Pathol 110:129-36, 1994. Pubmed reference: 8040380.
1989 Cordy, DR., Holliday, TA. :
A necrotizing meningoencephalitis of pug dogs. Vet Pathol 26:191-4, 1989. Pubmed reference: 2763409.

Edit History


  • Created by Frank Nicholas on 03 Jul 2009
  • Changed by Frank Nicholas on 22 May 2013