OMIA 001474-9615 : Rupture of the cranial cruciate ligament in Canis lupus familiaris

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific symbol: RCCL

Inheritance: Wilke et al. (2006) showed that this disorder is heritable, but the form of inheritance remains to be determined.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Baker, L.A., Kirkpatrick, B., Rosa, G.J., Gianola, D., Valente, B., Sumner, J.P., Baltzer, W., Hao, Z., Binversie, E.E., Volstad, N., Piazza, A., Sample, S.J., Muir, P. :
Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture. PLoS One 12:e0173810, 2017. Pubmed reference: 28379989. DOI: 10.1371/journal.pone.0173810.
Belanger, J.M., Bellumori, T.P., Bannasch, D.L., Famula, T.R., Oberbauer, A.M. :
Correlation of neuter status and expression of heritable disorders. Canine Genet Epidemiol 4:6, 2017. Pubmed reference: 28560045. DOI: 10.1186/s40575-017-0044-6.
Huang, M., Hayward, J.J., Corey, E., Garrison, S.J., Wagner, G.R., Krotscheck, U., Hayashi, K., Schweitzer, P.A., Lust, G., Boyko, A.R., Todhunter, R.J. :
A novel iterative mixed model to remap three complex orthopedic traits in dogs. PLoS One 12:e0176932, 2017. Pubmed reference: 28614352. DOI: 10.1371/journal.pone.0176932.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
2009 Clements, DN., Short, AD., Barnes, A., Kennedy, LJ., Ferguson, JF., Butterworth, SJ., Fitzpatrick, N., Pead, M., Bennett, D., Innes, JF., Carter, SD., Ollier, WE. :
A candidate gene study of canine joint diseases. J Hered 101:54-60, 2009. Pubmed reference: 19965910. DOI: 10.1093/jhered/esp088.
Wilke, VL., Zhang, S., Evans, RB., Conzemius, MG., Rothschild, MF. :
Identification of chromosomal regions associated with cranial cruciate ligament rupture in a population of Newfoundlands. Am J Vet Res 70:1013-7, 2009. Pubmed reference: 19645583. DOI: 10.2460/ajvr.70.8.1013.
2006 Wilke, VL., Conzemius, MG., Kinghorn, BP., Macrossan, PE., Cai, W., Rothschild, MF. :
Inheritance of rupture of the cranial cruciate ligament in Newfoundlands. J Am Vet Med Assoc 228:61-4, 2006. Pubmed reference: 16426167. DOI: 10.2460/javma.228.1.61.

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  • Created by Frank Nicholas on 27 Oct 2009