OMIA:001480-9823 : Melanoma, Melanoma-bearing Libĕchov Minipig (MeLiM) in Sus scrofa (pig)

Categories: Neoplasm

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific symbol: MeLiM stra

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001480-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Débare, H., Blanc, F., Piton, G., Leplat, J.J., Vincent-Naulleau, S., Rivière, J., Vilotte, M., Marthey, S., Lecardonnel, J., Coville, J.L., Estellé, J., Rau, A., Bourneuf, E., Egidy, G. :
Malignant features of minipig melanomas prior to spontaneous regression. Sci Rep 14:9240, 2024. Pubmed reference: 38649394. DOI: 10.1038/s41598-024-59741-w.
2019 Horak, V., Palanova, A., Cizkova, J., Miltrova, V., Vodicka, P., Kupcova Skalnikova, H. :
Melanoma-bearing Libechov minipig (MeLiM): The unique swine model of hereditary metastatic melanoma. Genes (Basel) 10:915, 2019. Pubmed reference: 31717496. DOI: 10.3390/genes10110915.
2017 Blanc, F., Créchet, F., Bruneau, N., Piton, G., Leplat, J.J., Andréoletti, F., Egidy, G., Vincent-Naulleau, S., Bourneuf, E. :
Impact of a CD4 gene haplotype on the immune response in minipigs. Immunogenetics , 2017. Pubmed reference: 29052750. DOI: 10.1007/s00251-017-1037-z.
Bourneuf, E. :
The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis. Front Genet 8:146, 2017. Pubmed reference: 29081790. DOI: 10.3389/fgene.2017.00146.
2014 Baco, M., Chu, C.Y., Bouet, S., Rogel-Gaillard, C., Bourneuf, E., Le Provost, F., Chu, C.Y., Vincent-Naulleau, S. :
Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs. Pigment Cell Melanoma Res 27:668-70, 2014. Pubmed reference: 24661544. DOI: 10.1111/pcmr.12243.
Fernández-Rodríguez, A., Estellé, J., Blin, A., Muñoz, M., Créchet, F., Demenais, F., Vincent-Naulleau, S., Bourneuf, E. :
KIT and melanoma predisposition in pigs: sequence variants and association analysis. Anim Genet , 2014. Pubmed reference: 24628300. DOI: 10.1111/age.12136.
2011 Bourneuf, E., Du, Z.Q., Estellé, J., Gilbert, H., Créchet, F., Piton, G., Milan, D., Geffrotin, C., Lathrop, M., Demenais, F., Rogel-Gaillard, C., Vincent-Naulleau, S. :
Genetic and functional evaluation of MITF as a candidate gene for cutaneous melanoma predisposition in pigs. Mamm Genome 22:602-12, 2011. Pubmed reference: 21626174. DOI: 10.1007/s00335-011-9334-6.
2008 Egidy, G., Julé, S., Bossé, P., Bernex, F., Geffrotin, C., Vincent-Naulleau, S., Horak, V., Sastre-Garau, X., Panthier, J.J. :
Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation. Mol Cancer 7:34, 2008. Pubmed reference: 18442364. DOI: 10.1186/1476-4598-7-34.
Rambow, F., Malek, O., Geffrotin, C., Leplat, J.J., Bouet, S., Piton, G., Hugot, K., Bevilacqua, C., Horak, V., Vincent-Naulleau, S. :
Identification of differentially expressed genes in spontaneously regressing melanoma using the MeLiM swine model. Pigment Cell Melanoma Res 21:147-61, 2008. Pubmed reference: 18426408. DOI: 10.1111/j.1755-148X.2008.00442.x.
Rambow, F., Piton, G., Bouet, S., Leplat, J.J., Baulande, S., Marrau, A., Stam, M., Horak, V., Vincent-Naulleau, S. :
Gene expression signature for spontaneous cancer regression in melanoma pigs. Neoplasia 10:714-26, 1 p following 726, 2008. Pubmed reference: 18592010.
2007 Du, Z.Q., Vincent-Naulleau, S., Gilbert, H., Vignoles, F., Créchet, F., Shimogiri, T., Yasue, H., Leplat, J.J., Bouet, S., Gruand, J., Horak, V., Milan, D., Le Roy, P., Geffrotin, C. :
Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model. Int J Cancer 120:303-20, 2007. Pubmed reference: 17066441. DOI: 10.1002/ijc.22289.
2004 Geffrotin, C., Crechet, F., Le Roy, P., Le Chalony, C., Leplat, JJ., Iannuccelli, N., Barbosa, A., Renard, C., Gruand, J., Milan, D., Horak, V., Tricaud, Y., Bouet, S., Franck, M., Frelat, G., Vincent-Naulleau, S. :
Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model. Int J Cancer 110:39-50, 2004. Pubmed reference: 15054867. DOI: 10.1002/ijc.20053.
Vincent-Naulleau, S., Le Chalony, C., Leplat, J.J., Bouet, S., Bailly, C., Spatz, A., Vielh, P., Avril, M.F., Tricaud, Y., Gruand, J., Horak, V., Frelat, G., Geffrotin, C. :
Clinical and histopathological characterization of cutaneous melanomas in the melanoblastoma-bearing Libechov minipig model. Pigment Cell Res 17:24-35, 2004. Pubmed reference: 14717842.
2003 Boisgard, R., Vincent-Naulleau, S., Leplat, J.J., Bouet, S., Le Chalony, C., Tricaud, Y., Horak, V., Geffrotin, C., Frelat, G., Tavitian, B. :
A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs. Eur J Nucl Med Mol Imaging 30:826-34, 2003. Pubmed reference: 12682788. DOI: 10.1007/s00259-003-1152-y.
Borovanský, J., Horák, V., Elleder, M., Fortýn, K., Smit, N.P., Kolb, A.M. :
Biochemical characterization of a new melanoma model--the minipig MeLiM strain. Melanoma Res 13:543-8, 2003. Pubmed reference: 14646615. DOI: 10.1097/01.cmr.0000056276.15046.21.
Le Chalony, C., Renard, C., Vincent-Naulleau, S., Crechet, F., Leplat, J.J., Tricaud, Y., Horak, V., Gruand, J., Le Roy, P., Frelat, G., Geffrotin, C. :
CDKN2A region polymorphism and genetic susceptibility to melanoma in the melim swine model of familial melanoma. Int J Cancer 103:631-5, 2003. Pubmed reference: 12494470. DOI: 10.1002/ijc.10871.
2000 Geffrotin, C., Horak, V., Créchet, F., Tricaud, Y., Lethias, C., Vincent-Naulleau, S., Vielh, P. :
Opposite regulation of tenascin-C and tenascin-X in MeLiM swine heritable cutaneous malignant melanoma. Biochim Biophys Acta 1524:196-202, 2000. Pubmed reference: 11113568.
1999 Horák, V., Fortýn, K., Hruban, V., Klaudy, J. :
Hereditary melanoblastoma in miniature pigs and its successful therapy by devitalization technique. Cell Mol Biol (Noisy-le-grand) 45:1119-29, 1999. Pubmed reference: 10644016.

Edit History

  • Created by Frank Nicholas on 01 Dec 2009
  • Changed by Imke Tammen2 on 22 Aug 2021