OMIA:001484-9685 : Coat colour, ticked (Abyssinian) in Felis catus
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal dominant
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2021
Species-specific symbol: Ti
Species-specific description: "Ticked" is the term applied to the non-tabby, agouti coat colour pattern that is the trade mark of Abyssinian cats. Its traditional symbol is T(a).
History: Lyons et al. (2021): "Ticked (previously known as Tabby), was the first locus to be regionally positioned to the centromeric region of cat chromosome B1q (Lyons et al. 2006). The ticked allele, formerly known as tabby – Aby (Ta), presents as a cat devoid of patterning, implying no stripes, blotches, swirls or spots – no tabby markings within the cat coat coloration ... . This allele is dominant, suppressing patterning, and hence epistatic to the LVRN Tabby locus, which controls the type of pattern, including mackerel (stripes) or classic (blotched) pattern."
Mapping: Lyons et al. (2006) mapped Abyssinian (Ta-) (at that time assumed to be an allele of the tabby locus) to chromosome B1.
Eizirik et al (2010) showed that the ticked phenotype is inherited independently of the two main tabby alleles, namely mackerel and blotched. The ticked locus maps to a 3.8Mb region on cat chromosome B1. The term "tabby locus", with its two alleles mackerel and blotched, is now reserved for a locus on cat chromosome A1 (see Coat colour, tabby; OMIA 001429-9685).
Molecular basis: Lyons et al. (2021; published 29 March): "The cat reference genome (Cinnamon, the Abyssinian) has the ticked phenotype and the variant dataset and coat phenotypes from the 99 Lives Cat Genome Consortium (195 cats) were used to identify candidate genes and variants associated with the Ticked locus. ... two variants in Dickkopf Wnt Signaling Pathway Inhibitor 4 (DKK4), a p.Cys63Tyr (B1:4621481, c.188G>A) and a less common p.Ala18Val (B1:42620835, c.53C>T) variant are suggested as two alleles influencing the Ticked phenotype. ... Cinnamon was a compound heterozygous for the p.Cys63Tyr/p.Ala18Val variants."
In a study in which they "applied morphological and single-cell gene expression analysis to fetal skin of domestic cats", Kaelin et al. (2021; published 7 Sept) discovered the same two variants having the same phenotypic effects.
Breeds: Abyssinian (Cat) (VBO_0100000), Burmese (Cat) (VBO_0100053), Oriental Shorthair (Cat) (VBO_0100184), Singapura (Cat) (VBO_0100224).
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|DKK4||dickkopf WNT signaling pathway inhibitor 4||Felis catus||B1||NC_058371.1 (40428737..40431634)||DKK4||Homologene, Ensembl , NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1308||Abyssinian (Cat) Burmese (Cat) Maine Coon (Cat) Oriental Shorthair (Cat)||Ticked||DKK4||Ti^CK||missense||Naturally occurring variant||Felis_catus_9.0||B1||g.42620835C>T||c.53C>T||p.(A18V)||2021||33780570||ENSFCAT00000034752:c.53C>T; XM_023252567.1:c53C>T|
|1307||Abyssinian (Cat)||Ticked||DKK4||Ti^A||missense||Naturally occurring variant||Felis_catus_9.0||B1||g.42621481G>A||c.188G>A||p.(C63Y)||published as g.41621481G>A||rs785541575||2021||33780570||(XM_023252567.1; ENSFCAT00000034752: c.188G>A)|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Kaelin, C.B., McGowan, K.A., Barsh, G.S. :|
|Developmental genetics of color pattern establishment in cats. Nat Commun 12:5127, 2021. Pubmed reference: 34493721 . DOI: 10.1038/s41467-021-25348-2.|
|Lyons, L.A., Buckley, R.M., Harvey, R.J. :|
|Mining the 99 lives cat genome sequencing consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus). Anim Genet :, 2021. Pubmed reference: 33780570 . DOI: 10.1111/age.13059.|
|2010||Eizirik, E., David, VA., Buckley-Beason, V., Roelke, ME., Schaffer, AA., Hannah, SS., Narfstrom, K., O'Brien, SJ., Menotti-Raymond, M. :|
|Defining and mapping mammalian coat pattern genes: multiple genomic regions implicated in domestic cat stripes and spots. Genetics 184:267-75, 2010. Pubmed reference: 19858284 . DOI: 10.1534/genetics.109.109629.|
|2006||Lyons, LA., Bailey, SJ., Baysac, KC., Byrns, G., Erdman, CA., Fretwell, N., Froenicke, L., Gazlay, KW., Geary, LA., Grahn, JC., Grahn, RA., Karere, GM., Lipinski, MJ., Rah, H., Ruhe, MT., Bach, LH. :|
|The Tabby cat locus maps to feline chromosome B1. Anim Genet 37:383-6, 2006. Pubmed reference: 16879352 . DOI: 10.1111/j.1365-2052.2006.01458.x.|
|1988||Lomax, T.D., Robinson, R. :|
|Tabby pattern alleles of the domestic cat Journal of Heredity 79:21-23, 1988. Pubmed reference: 3367033 .|
- Created by Frank Nicholas on 06 Apr 2010
- Changed by Frank Nicholas on 18 Oct 2012
- Changed by Imke Tammen2 on 14 Apr 2021
- Changed by Frank Nicholas on 09 Sep 2021
- Changed by Imke Tammen2 on 17 Nov 2021