OMIA 001484-9685 : Coat colour, ticked (Abyssinian) in Felis catus

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2021

Species-specific symbol: Ti

Species-specific description: "Ticked" is the term applied to the non-tabby, agouti coat colour pattern that is the trade mark of Abyssinian cats. Its traditional symbol is T(a).

History: Lyons et al. (2021): "Ticked (previously known as Tabby), was the first locus to be regionally positioned to the centromeric region of cat chromosome B1q (Lyons et al. 2006). The ticked allele, formerly known as tabby – Aby (Ta), presents as a cat devoid of patterning, implying no stripes, blotches, swirls or spots – no tabby markings within the cat coat coloration ... . This allele is dominant, suppressing patterning, and hence epistatic to the LVRN Tabby locus, which controls the type of pattern, including mackerel (stripes) or classic (blotched) pattern."

Mapping: Lyons et al. (2006) mapped Abyssinian (Ta-) (at that time assumed to be an allele of the tabby locus) to chromosome B1.

Eizirik et al (2010) showed that the ticked phenotype is inherited independently of the two main tabby alleles, namely mackerel and blotched. The ticked locus maps to a 3.8Mb region on cat chromosome B1. The term "tabby locus", with its two alleles mackerel and blotched, is now reserved for a locus on cat chromosome A1 (see Coat colour, tabby; OMIA 001429-9685).

Molecular basis: Lyons et al. (2021): "The cat reference genome (Cinnamon, the Abyssinian) has the ticked phenotype and the variant dataset and coat phenotypes from the 99 Lives Cat Genome Consortium (195 cats) were used to identify candidate genes and variants associated with the Ticked locus. ... two variants in Dickkopf Wnt Signaling Pathway Inhibitor 4 (DKK4), a p.Cys63Tyr (B1:41621481, c.188G>A) and a less common p.Ala18Val (B1:42620835, c.53C>T) variant are suggested as two alleles influencing the Ticked phenotype. ... Cinnamon was a compound heterozygous for the p.Cys63Tyr/p.Ala18Val variants."

Breeds: Abyssinian, Burmese, Oriental shorthair, Singapura.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
DKK4 dickkopf WNT signaling pathway inhibitor 4 Felis catus B1 NC_018726.3 (42620726..42623627) DKK4 Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Abyssinian Ticked DKK4 Ti^A missense Felis_catus_9.0 B1 g.41621481G>A c.188G>A p.(Cys63Tyr) 2021 33780570 (XM_023252567.1; ENSFCAT00000034752: c.188G>A)
Abyssinian Burmese Maine Coon Oriental shorthair Ticked DKK4 Ti^CK missense Felis_catus_9.0 B1 g.42620835C>T c.53C>T p.(Ala18Val) 2021 33780570 ENSFCAT00000034752:c.53C>T; XM_023252567.1:c53C>T

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Lyons, L.A., Buckley, R.M., Harvey, R.J. :
Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus). Anim Genet :, 2021. Pubmed reference: 33780570. DOI: 10.1111/age.13059.
2010 Eizirik, E., David, VA., Buckley-Beason, V., Roelke, ME., Schaffer, AA., Hannah, SS., Narfstrom, K., O'Brien, SJ., Menotti-Raymond, M. :
Defining and mapping mammalian coat pattern genes: multiple genomic regions implicated in domestic cat stripes and spots. Genetics 184:267-75, 2010. Pubmed reference: 19858284. DOI: 10.1534/genetics.109.109629.
2006 Lyons, LA., Bailey, SJ., Baysac, KC., Byrns, G., Erdman, CA., Fretwell, N., Froenicke, L., Gazlay, KW., Geary, LA., Grahn, JC., Grahn, RA., Karere, GM., Lipinski, MJ., Rah, H., Ruhe, MT., Bach, LH. :
The Tabby cat locus maps to feline chromosome B1. Anim Genet 37:383-6, 2006. Pubmed reference: 16879352. DOI: 10.1111/j.1365-2052.2006.01458.x.
1988 Lomax, T.D., Robinson, R. :
Tabby pattern alleles of the domestic cat Journal of Heredity 79:21-23, 1988. Pubmed reference: 3367033.

Edit History


  • Created by Frank Nicholas on 06 Apr 2010
  • Changed by Frank Nicholas on 18 Oct 2012
  • Changed by Imke Tammen2 on 14 Apr 2021