OMIA 001512-9615 : Invasive transitional cell carcinoma in Canis lupus familiaris |
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
BRAF | B-Raf proto-oncogene, serine/threonine kinase | Canis lupus familiaris | 16 | NC_051820.1 (8065738..8237942) | BRAF | Homologene, Ensembl, NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Inferred EVA rsID | Year Published | PubMed ID(s) | Acknowledgements |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
93 | Invasive transitional cell carcinoma of the bladder | BRAF | missense | Naturally occurring variant | CanFam3.1 | 16 | g.8296284T>A | c.1643T>A | p.(V548E) | XM_005629551.3; XP_005629608.1; published as somatic mutation p.(V594E) | 2015 | 25767210 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 | Gedon, J., Kehl, A., Aupperle-Lellbach, H., von Bomhard, W., Schmidt, J.M. : | |
BRAF mutation status and its prognostic significance in 79 canine urothelial carcinomas: A retrospective study (2006-2019). Vet Comp Oncol :, 2021. Pubmed reference: 34878687. DOI: 10.1111/vco.12790. | ||
Rossman, P., Zabka, T.S., Ruple, A., Tuerck, D., Ramos-Vara, J.A., Liu, L., Mohallem, R., Merchant, M., Franco, J., Fulkerson, C.M., Bhide, K.P., Breen, M., Aryal, U.K., Murray, E.R., Dybdal, N., Utturkar, S.M., Fourez, L.M., Enstrom, A.W., Dhawan, D., Knapp, D.W. : | ||
Phase I / II trial of vemurafenib in dogs with naturally-occurring, BRAF-mutated urothelial carcinoma. Mol Cancer Ther :, 2021. Pubmed reference: 34433660. DOI: 10.1158/1535-7163.MCT-20-0893. | ||
2019 | Grassinger, J.M., Aupperle-Lellbach, H., Erhard, H., Merz, S., Klopfleisch, R. : | |
[Detection of BRAF mutation in canine prostatic diseases]. Tierarztl Prax Ausg K Kleintiere Heimtiere 47:313-320, 2019. Pubmed reference: 31627222. DOI: 10.1055/a-0987-8212. | ||
2015 | Decker, B., Parker, H.G., Dhawan, D., Kwon, E.M., Karlins, E., Davis, B.W., Ramos-Vara, J.A., Bonney, P.L., McNiel, E.A., Knapp, D.W., Ostrander, E.A. : | |
Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Mol Cancer Res 13:993-1002, 2015. Pubmed reference: 25767210. DOI: 10.1158/1541-7786.MCR-14-0689. | ||
2004 | Glickman, LT., Raghavan, M., Knapp, DW., Bonney, PL., Dawson, MH. : | |
Herbicide exposure and the risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers. J Am Vet Med Assoc 224:1290-7, 2004. Pubmed reference: 15112777. | ||
2000 | Knapp, D., Glickman, N., DeNicola, D., Bonney, P., Lin, T., Glickman, L. : | |
Naturally-occurring canine transitional cell carcinoma of the urinary bladder: A relevant model of human invasive bladder cancer Urology Oncology 5:47-59, 2000. | ||
1989 | Glickman, LT., Schofer, FS., McKee, LJ., Reif, JS., Goldschmidt, MH. : | |
Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs. J Toxicol Environ Health 28:407-14, 1989. Pubmed reference: 2593174. DOI: 10.1080/15287398909531360. | ||
1976 | Hayes, HM. : | |
Canine bladder cancer: epidemiologic features. Am J Epidemiol 104:673-7, 1976. Pubmed reference: 998613. |
Edit History
- Created by Frank Nicholas on 02 Nov 2010
- Changed by Frank Nicholas on 24 Mar 2015
- Changed by Frank Nicholas on 23 Jan 2018
- Changed by Frank Nicholas on 23 Oct 2019
- Changed by Frank Nicholas on 15 May 2020
- Changed by Imke Tammen2 on 19 Apr 2021
- Changed by Imke Tammen2 on 17 Sep 2021