OMIA 001528-9940 : Fleece variation (woolly vs hairy) in Ovis aries
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|IRF2BP2||interferon regulatory factor 2 binding protein 2||Ovis aries||25||NC_056078.1 (6785991..6782529)||IRF2BP2||Homologene, Ensembl, NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|805||Romane||Fleece variation, woolly||IRF2BP2||insertion, gross (>20)||Naturally occurring variant||Oar_rambouillet_v1.0||25||insertion of an antisense EIF2S2 retrogene (called asEIF2S2) into the 3' UTR of the IRF2BP2 gene||2017||28379502|
|2017||Demars, J., Cano, M., Drouilhet, L., Plisson-Petit, F., Bardou, P., Fabre, S., Servin, B., Sarry, J., Woloszyn, F., Mulsant, P., Foulquier, D., Carrière, F., Aletru, M., Rodde, N., Cauet, S., Bouchez, O., Pirson, M., Tosser-Klopp, G., Allain, D. :|
|Genome-wide identification of the mutation underlying fleece variation and discriminating ancestral hairy species from modern woolly sheep. Mol Biol Evol 34:1722-1729, 2017. Pubmed reference: 28379502. DOI: 10.1093/molbev/msx114.|
- Created by Frank Nicholas on 01 Sep 2017
- Changed by Frank Nicholas on 01 Sep 2017