OMIA 001530-9615 : Compulsive disorder in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s) (MIM number): 164230

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: By conducting a GWAS on 92 affected and 68 control Doberman pinschers, each genotyped with the Affymetrix v2 canine SNP chip (yielding 14,700 informative SNPs for analysis), Dodman et al. (2010) highlighted a 1.7Mb region on chromosome CFA7. Fine-mapping narrowed the candidate region to 400kb, which includes the gene CDH2, which "is widely expressed, mediating synaptic activity-regulated neuronal adhesion". A SNP in this gene showed the strongest association with the disorder.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2014 Tang, R., Noh, H.J., Wang, D., Sigurdsson, S., Swofford, R., Perloski, M., Duxbury, M., Patterson, E.E., Albright, J., Castelhano, M., Auton, A., Boyko, A.R., Feng, G., Lindblad-Toh, K., Karlsson, E.K. :
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. Genome Biol 15:R25, 2014. Pubmed reference: 24995881. DOI: 10.1186/gb-2014-15-3-r25.
2013 Ogata, N., Gillis, T.E., Liu, X., Cunningham, S.M., Lowen, S.B., Adams, B.L., Sutherland-Smith, J., Mintzopoulos, D., Janes, A.C., Dodman, N.H., Kaufman, M.J. :
Brain structural abnormalities in Doberman pinschers with canine compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry :, 2013. Pubmed reference: 23590875. DOI: 10.1016/j.pnpbp.2013.04.002.
2010 Dodman, NH., Karlsson, EK., Moon-Fanelli, A., Galdzicka, M., Perloski, M., Shuster, L., Lindblad-Toh, K., Ginns, EI. :
A canine chromosome 7 locus confers compulsive disorder susceptibility. Mol Psychiatry 15:8-10, 2010. Pubmed reference: 20029408. DOI: 10.1038/mp.2009.111.
2007 [No authors listed] :
Animal behavior case of the month. Canine compulsive disorder. J Am Vet Med Assoc 231:536-9, 2007. Pubmed reference: 17696852. DOI: 10.2460/javma.231.4.536.
1992 Ross, PE. :
Compulsive canines. Sci Am 267:24-6, 1992. Pubmed reference: 1502507.

Edit History


  • Created by Frank Nicholas on 05 Nov 2010
  • Changed by Frank Nicholas on 21 May 2013