OMIA 001566-9986 : Rex coat in Oryctolagus cuniculus
Category: Integument (skin) phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2011
Species-specific name: French rex; Gillet rex; Franz. Rex
Species-specific symbol: rex; r1
Species-specific description: See Robinson (1958, pp. 298-300).
History: This is the first of three rex mutant phenotypes to be described. As summarised by Diribarne et al. (2011), "In 1919 in the Pays de Loire French region, a mutant phenotype with soft hair was observed by a breeder in a litter of wild gray rabbits. Abbé Gillet, a local priest, considered the trait very fancy and started planning crosses to produce rabbits with this soft hair touching phenotype with guard hair that was no longer than the undercoat."
Mapping: Castle and Nachtsheim (1933) showed that r1 rex is linked to r2 rex (OMIA 002005-9986) with a recombination frequency of 10-12%. These same authors showed that the third type of rex in rabbits, r3 (OMIA 002006-9986), segregates independently of r1 and r2.
Molecular basis: Diribarne et al (2011) showed that the r1 rex hair coat phenotype in rabbits is due to a single nucleotide deletion in exon 9 of the LIPH gene.
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|LIPH||lipase, member H||Oryctolagus cuniculus||14||NC_067387.1 (81155289..81266104)||LIPH||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|450||Rex coat||LIPH||deletion, small (<=20)||Naturally occurring variant||14||c.1362delA||2011||21552526|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Dorożyńska, K., Maj, D. :|
|Rabbits - their domestication and molecular genetics of hair coat development and quality. Anim Genet 52:10-20, 2021. Pubmed reference: 33216407. DOI: 10.1111/age.13024.|
|2018||Chen, Y., Zhao, B., Liu, M., Wang, J., Qiu, X., Zhu, C., Wu, X. :|
|MicroRNAs Profiling Identifies miR-125a and Its Target Gene Wnt2 in Skins of Different Haired Rabbits. Front Genet 9:628, 2018. Pubmed reference: 30619457. DOI: 10.3389/fgene.2018.00628.|
|2017||Zhao, B., Chen, Y., Yan, X., Hao, Y., Zhu, J., Weng, Q., Wu, X. :|
|Gene expression profiling analysis reveals fur development in rex rabbits (Oryctolagus cuniculus). Genome 60:1060-1067, 2017. Pubmed reference: 28850794. DOI: 10.1139/gen-2017-0003.|
|2016||Leroy, G., Besbes, B., Boettcher, P., Hoffmann, I., Capitan, A., Baumung, R. :|
|Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet 47:141-53, 2016. Pubmed reference: 26662214. DOI: 10.1111/age.12393.|
|2012||Diribarne, M., Mata, X., Rivière, J., Bouet, S., Vaiman, A., Chapuis, J., Reine, F., Fleurot, R., Auvinet, G., Deretz, S., Allain, D., Schibler, L., Cribiu, E.P., Guérin, G. :|
|LIPH expression in skin and hair follicles of normal coat and Rex rabbits. PLoS One 7:e30073, 2012. Pubmed reference: 22272275. DOI: 10.1371/journal.pone.0030073.|
|2011||Chen, S.J., Liu, T., Liu, Y.J., Dong, B., Huang, Y.T., Gu, Z.L. :|
|Identification of single nucleotide polymorphisms in the CCNA2 gene and its association with wool density in Rex rabbits. Genet Mol Res 10:3365-70, 2011. Pubmed reference: 22095474. DOI: 10.4238/2011.November.4.1.|
|Diribarne, M., Mata, X., Chantry-Darmon, C., Vaiman, A., Auvinet, G., Bouet, S., Deretz, S., Cribiu, E.P., de Rochambeau, H., Allain, D., Guérin, G. :|
|A deletion in exon 9 of the LIPH gene is responsible for the rex hair coat phenotype in rabbits (Oryctolagus cuniculus). PLoS One 6:e19281, 2011. Pubmed reference: 21552526. DOI: 10.1371/journal.pone.0019281.|
|1958||Robinson, R. :|
|Genetic studies of the rabbit. Bibliographia Genetica 17:229–558, 1958.|
|1933||Castle, WE., Nachtsheim, H. :|
|Linkage interrelations of three genes for rex (short) coat in the rabbit. Proc Natl Acad Sci U S A 19:1006-11, 1933. Pubmed reference: 16587815.|
|1929||Castle, W.E. :|
|The rex rabbit Journal of Heredity 20:193-199, 1929.|
- Created by Frank Nicholas on 27 May 2011
- Changed by Frank Nicholas on 07 Sep 2011
- Changed by Frank Nicholas on 09 Dec 2011
- Changed by Frank Nicholas on 03 May 2016