OMIA:001573-9615 : Leukemia, chronic monocytic in Canis lupus familiaris |
Categories: Neoplasm
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151410 (gene) , 608232 (trait) , 189980 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Somatic mutation
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2011
Species-specific name: Chronic monocytic leukemia
Species-specific symbol: CMoL
Molecular basis: Cruz Cardona et al. (2011) reported the first identified case of an animal equivalent of "Philadelphia chromosome" - a chromosomal translocation that results in chronic leukemia. This translocation involves the gene known as breakpoint cluster region (BCR).
Associated genes:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| BCR | breakpoint cluster region | Canis lupus familiaris | 26 | NC_051830.1 (29260365..29385328) | BCR | Homologene, Ensembl , NCBI gene |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | Canis lupus familiaris | 9 | NC_051813.1 (54162127..54019016) | ABL1 | Homologene, Ensembl , NCBI gene |
Reference
| 2011 | Cruz Cardona, JA., Milner, R., Alleman, AR., Williams, C., Vernau, W., Breen, M., Tompkins, M. : |
| BCR-ABL translocation in a dog with chronic monocytic leukemia. Vet Clin Pathol 40:40-7, 2011. Pubmed reference: 21143615 . DOI: 10.1111/j.1939-165X.2010.00277.x. |
Edit History
- Created by Frank Nicholas on 12 Jul 2011
- Changed by Frank Nicholas on 28 Sep 2011
- Changed by Frank Nicholas on 12 Dec 2011
- Changed by Imke Tammen2 on 08 Dec 2020
- Changed by Imke Tammen2 on 10 Dec 2020