OMIA 001573-9615 : Leukemia, chronic monocytic in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151410 , 608232

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2011

Species-specific name: Chronic monocytic leukemia

Species-specific symbol: CMoL

Molecular basis: Cruz Cardona et al. (2011) reported the first identified case of an animal equivalent of "Philadelphia chromosome" - a chromosomal translocation that results in chronic leukemia. This translocation involves the gene known as breakpoint cluster region (BCR).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
BCR breakpoint cluster region Canis lupus familiaris 26 NC_006608.3 (27856280..27980923) BCR Homologene, Ensembl, NCBI gene

Variants

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
mixed breed Leukemia, chronic monocytic BCR complex rearrangement "Philadelphia chromosome" - a chromosomal translocation that results in chronic leukemia. This translocation involves the gene known as breakpoint cluster region (BCR). 2011 21143615

Reference


2011 Cruz Cardona, JA., Milner, R., Alleman, AR., Williams, C., Vernau, W., Breen, M., Tompkins, M. :
BCR-ABL translocation in a dog with chronic monocytic leukemia. Vet Clin Pathol 40:40-7, 2011. Pubmed reference: 21143615. DOI: 10.1111/j.1939-165X.2010.00277.x.

Edit History


  • Created by Frank Nicholas on 12 Jul 2011
  • Changed by Frank Nicholas on 28 Sep 2011
  • Changed by Frank Nicholas on 12 Dec 2011