OMIA 001573-9615 : Leukemia, chronic monocytic in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151410 (gene) , 608232 (trait) , 189980 (gene)

Mendelian trait/disorder: no

Mode of inheritance: Somatic Mutation

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2011

Species-specific name: Chronic monocytic leukemia

Species-specific symbol: CMoL

Molecular basis: Cruz Cardona et al. (2011) reported the first identified case of an animal equivalent of "Philadelphia chromosome" - a chromosomal translocation that results in chronic leukemia. This translocation involves the gene known as breakpoint cluster region (BCR).

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
BCR breakpoint cluster region Canis lupus familiaris 26 NC_051830.1 (29260365..29385328) BCR Homologene, Ensembl, NCBI gene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase Canis lupus familiaris 9 NC_051813.1 (54162127..54019016) ABL1 Homologene, Ensembl, NCBI gene

Reference


2011 Cruz Cardona, JA., Milner, R., Alleman, AR., Williams, C., Vernau, W., Breen, M., Tompkins, M. :
BCR-ABL translocation in a dog with chronic monocytic leukemia. Vet Clin Pathol 40:40-7, 2011. Pubmed reference: 21143615. DOI: 10.1111/j.1939-165X.2010.00277.x.

Edit History


  • Created by Frank Nicholas on 12 Jul 2011
  • Changed by Frank Nicholas on 28 Sep 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Imke Tammen2 on 08 Dec 2020
  • Changed by Imke Tammen2 on 10 Dec 2020