OMIA 001576-30521 : Coat colour, colour-sided in Bos grunniens

In other species: cattle

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2014

Molecular basis: Zhang et al. (2014) reported the same molecular basis of colour-sidedness in yaks as in cattle, namely (as reported by Durkin et al., 2012) "colour sidedness is determined by a first allele on chromosome 29 (Cs(29)), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs(6)), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus" [see OMIA 001576-9913]

Medugorac et al. (2017) provided evidence that the colour-sided variant in yaks is due to introgression into yaks from Mongolian Turano cattle that have been herded with Mongolian yaks for more than 1,500 years, enabling the backcrossing of female yak-cattle hybrids to male yaks.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Bos mutus - no genomic information (-..-) KIT Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Medugorac, I., Graf, A., Grohs, C., Rothammer, S., Zagdsuren, Y., Gladyr, E., Zinovieva, N., Barbieri, J., Seichter, D., Russ, I., Eggen, A., Hellenthal, G., Brem, G., Blum, H., Krebs, S., Capitan, A. :
Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks. Nat Genet 49:470-475, 2017. Pubmed reference: 28135247. DOI: 10.1038/ng.3775.
2014 Zhang, M.Q., Xu, X., Luo, S.J. :
The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens). Anim Genet 45:652-9, 2014. Pubmed reference: 24989079. DOI: 10.1111/age.12191.
2012 Durkin, K., Coppieters, W., Drögemüller, C., Ahariz, N., Cambisano, N., Druet, T., Fasquelle, C., Haile, A., Horin, P., Huang, L., Kamatani, Y., Karim, L., Lathrop, M., Moser, S., Oldenbroek, K., Rieder, S., Sartelet, A., Sölkner, J., Stålhammar, H., Zelenika, D., Zhang, Z., Leeb, T., Georges, M., Charlier, C. :
Serial translocation by means of circular intermediates underlies colour sidedness in cattle. Nature 482:81-4, 2012. Pubmed reference: 22297974. DOI: 10.1038/nature10757.

Edit History


  • Created by Frank Nicholas on 30 Apr 2015
  • Changed by Frank Nicholas on 30 Apr 2015
  • Changed by Frank Nicholas on 04 Oct 2017