OMIA:001580-9685 : Feet, white (gloving) in Felis catus (domestic cat)

Categories: Pigmentation phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 164920 (gene) , 172800 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2010

Species-specific name: Gloves

Molecular basis: Lyons (2010) included this trait in a list of traits for which a DNA test is available, stating the cause as a deletion/insertion in the KIT gene (c.1035_1036delinsCA). She cited a paper by Gandolfi B, Bach L, Beresford L, et al., which had not yet been published. This variant was published by Montague et al. (2014).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Prevalence: Montague et al. (2014): "Genotyping these [two adjacent KIT] SNPs in a larger sample including 150 Birman cats and 729 additional cats confirmed that all Birman cats were homozygous for both SNPs and that all first-generation outcrossed Birman cats with no gloving were carriers of the polymorphisms".

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Felis catus B1 NC_058371.1 (161389917..161303938) KIT Homologene, Ensembl , NCBI gene


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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Inferred EVA rsID Year Published PubMed ID(s) Acknowledgements
620 Birman (Cat) Feet white (gloving) KIT g delins, small (<=20) Naturally occurring variant Felis_catus_9.0 B1 g.163986474_163986475delinsTG c.1035_1036delinsCA p.(E345_H346delinsDN) NM_001009837.3; NP_001009837.3; Montague et al. (2014) describe this variant as "two adjacent missense mutations". 2010 21147473 Genomic position in Felis_catus_9.0 provided by Leslie Lyons and Reuben Buckley.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001580-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2014 Montague, M.J., Li, G., Gandolfi, B., Khan, R., Aken, B.L., Searle, S.M., Minx, P., Hillier, L.W., Koboldt, D.C., Davis, B.W., Driscoll, C.A., Barr, C.S., Blackistone, K., Quilez, J., Lorente-Galdos, B., Marques-Bonet, T., Alkan, C., Thomas, G.W., Hahn, M.W., Menotti-Raymond, M., O'Brien, S.J., Wilson, R.K., Lyons, L.A., Murphy, W.J., Warren, W.C. :
Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication. Proc Natl Acad Sci U S A 111:17230-5, 2014. Pubmed reference: 25385592. DOI: 10.1073/pnas.1410083111.
2010 Lyons, LA. :
Feline genetics: clinical applications and genetic testing. Top Companion Anim Med 25:203-12, 2010. Pubmed reference: 21147473. DOI: 10.1053/j.tcam.2010.09.002.

Edit History

  • Created by Frank Nicholas on 20 Jul 2011
  • Changed by Frank Nicholas on 10 Sep 2011
  • Changed by Frank Nicholas on 09 Dec 2011
  • Changed by Frank Nicholas on 23 Nov 2012
  • Changed by Frank Nicholas on 15 May 2020
  • Changed by Frank Nicholas on 09 Jan 2021
  • Changed by Imke Tammen2 on 26 Aug 2023