OMIA:001598-9940 : Wool shedding in Ovis aries (sheep)
Categories: Integument (skin) phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal dominant
Considered a defect: no
Key variant known: no
Cross-species summary: The fleece is shed naturally on an annual basis.
Species-specific name: Fleece shedding
Inheritance: A segregation analysis reported by Pollott (2011) provided evidence for an autosomal dominant gene of large effect associated with natural wool shedding in a flock comprising a mixture of shedding breeds. When scored on a 5-point scale (1 = no shedding; 5 = complete shedding), shedding was reported to have a heritability of 0.54 in lambs and 0.26 across all ages. Matika et al. (2013) "found strong genetic control for wool shedding, demonstrated the possibility of a single putative dominant gene controlling this trait and identified four SNPs that may be in partial linkage disequilibrium with gene(s) controlling shedding."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2013||Matika, O., Bishop, S.C., Pong-Wong, R., Riggio, V., Headon, D.J. :|
|Genetic factors controlling wool shedding in a composite Easycare sheep flock. Anim Genet , 2013. Pubmed reference: 23837698. DOI: 10.1111/age.12070.|
|2011||Pollott, G.E. :|
|A suggested mode of inheritance for wool shedding in sheep. J Anim Sci 89:2316-25, 2011. Pubmed reference: 21357446. DOI: 10.2527/jas.2010-3713.|
|1980||Meyer, W., Neurand, K., Schwarz, R. :|
|[Hair shedding and replacement in domestic mammals.--3. Hair shedding and replacement in sheep and goat (author's transl)]. Dtsch Tierarztl Wochenschr 87:346-53, 1980. Pubmed reference: 7006996.|
|1965||Ryder, M.L. :|
|Wool fibre shedding and seasonal variation in wool growth. Proc R Soc Med 58:806-8, 1965. Pubmed reference: 5891124.|
- Created by Frank Nicholas on 07 Sep 2011
- Changed by Frank Nicholas on 07 Sep 2011
- Changed by Frank Nicholas on 12 Jul 2013