OMIA 001608-9615 : May-Hegglin anomaly in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s) (MIM number): 155100

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2011

Species-specific symbol: MHA

Breed: Pug.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MYH9 myosin, heavy chain 9, non-muscle Canis lupus familiaris 10 NC_006592.3 (28063626..28122953) MYH9 Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Pug May-Hegglin anomaly MYH9 missense p.Q1841L 2011 21554370

Reference


2011 Flatland, B., Fry, M.M., Baek, S.J., Bahn, J.H., LeBlanc, C.J., Dunlap, J.R., Carroll, R.C., Kosiba, D.J., Millsaps, D.J., Schleis, S.E. :
May-Hegglin anomaly in a dog. Vet Clin Pathol 40:207-14, 2011. Pubmed reference: 21554370. DOI: 10.1111/j.1939-165X.2011.00320.x.

Edit History


  • Created by Frank Nicholas on 26 Sep 2011
  • Changed by Frank Nicholas on 12 Dec 2011