OMIA 001652-9627 : Coat colour, platinum in Vulpes vulpes

In other species: North American deer mouse

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2015

Molecular basis: "A single nucleotide polymorphism (SNP) was identified at the first nucleotide of KIT intron 17 in the platinum fox. In platinum foxes, the A allele of the SNP disrupts the donor splice site and causes exon 17, which is part of a segment that encodes a conserved tyrosine kinase domain, to be skipped" (Johnson et al., 2015)

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
KIT Vulpes lagopus - no genomic information (-..-) KIT Ensembl

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Kukekova, A.V., Johnson, J.L., Kharlamova, A.V., Vladimirova, A.V., Shepeleva, D.V., Gulevich, R.G., Trut, L.N. :
Georgian white coat color of red fox (Vulpes vulpes) maps to fox chromosome 2 in the region containing KIT gene. Anim Genet 47:514-5, 2016. Pubmed reference: 27329365. DOI: 10.1111/age.12439.
2015 Johnson, J.L., Kozysa, A., Kharlamova, A.V., Gulevich, R.G., Perelman, P.L., Fong, H.W., Vladimirova, A.V., Oskina, I.N., Trut, L.N., Kukekova, A.V. :
Platinum coat color in red fox (Vulpes vulpes) is caused by a mutation in an autosomal copy of KIT. Anim Genet 46:190-9, 2015. Pubmed reference: 25662789. DOI: 10.1111/age.12270.

Edit History


  • Created by Frank Nicholas on 29 Apr 2015
  • Changed by Frank Nicholas on 29 Apr 2015