OMIA:001687-9615 : Inflammatory bowel disease in Canis lupus familiaris (dog)

In other species: domestic cat , horse , pig , maned wolf

Categories: Digestive / alimentary phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 266600 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: The term 'inflammatory bowel disease' has been used historically to describe canine chronic enteropathy / chronic inflammatory enteropathy (CIE)

Species-specific symbol: IBD; CIE

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Prevalence: From a survey of case reports of dogs in south-eastern UK, Kathrani et al. (2011) reported several breeds listed on this page as being at significantly higher risk of developing IBD.

Breeds: Border Collie (Dog) (VBO_0200193), Boxer (Dog) (VBO_0200210), Dachshund, Miniature (Dog) (VBO_0200408), French Bulldog (Dog) (VBO_0201455), German Shepherd Dog (Dog) (VBO_0200577), Rottweiler (Dog) (VBO_0201143), Weimaraner (Dog) (VBO_0201401).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001687-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Kather, S., Kacza, J., Pfannkuche, H., Böttcher, D., Sung, C.H., Steiner, J.M., Gäbel, G., Dengler, F., Heilmann, R.M. :
Expression of the cobalamin transporters cubam and MRP1 in the canine ileum-Upregulation in chronic inflammatory enteropathy. PLoS One 19:e0296024, 2024. Pubmed reference: 38206981. DOI: 10.1371/journal.pone.0296024.
Pratscher, B., Kuropka, B., Csukovich, G., Doulidis, P.G., Spirk, K., Kramer, N., Freund, P., Rodríguez-Rojas, A., Burgener, I.A. :
Traces of canine inflammatory bowel disease reflected by intestinal organoids. Int J Mol Sci 25:576, 2024. Pubmed reference: 38203746. DOI: 10.3390/ijms25010576.
2023 Cagnasso, F., Borrelli, A., Bottero, E., Benvenuti, E., Ferriani, R., Marchetti, V., Ruggiero, P., Bruno, B., Maurella, C., Gianella, P. :
Comparative evaluation of peripheral blood neutrophil to lymphocyte ratio, serum albumin to globulin ratio and serum C-reactive protein to albumin ratio in dogs with inflammatory protein-losing enteropathy and healthy dogs. Animals (Basel) 13:484, 2023. Pubmed reference: 36766371. DOI: 10.3390/ani13030484.
Collins-Webb, A.G., Chong, D., Cooley, S.D. :
Ultrasonographic intestinal muscularis thickening in dogs with histologically confirmed inflammatory bowel disease: 13 cases (2010-2021). Vet Radiol Ultrasound 64:345-350, 2023. Pubmed reference: 36307900. DOI: 10.1111/vru.13173.
Dengler, F., Domenig, O., Kather, S., Burgener, I.A., Steiner, J.M., Heilmann, R.M. :
Dysregulation of intestinal epithelial electrolyte transport in canine chronic inflammatory enteropathy and the role of the renin-angiotensin-aldosterone-system. Front Vet Sci 10:1217839, 2023. Pubmed reference: 37720474. DOI: 10.3389/fvets.2023.1217839.
Doulidis, P.G., Galler, A.I., Hausmann, B., Berry, D., Rodríguez-Rojas, A., Burgener, I.A. :
Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission. Sci Rep 13:4337, 2023. Pubmed reference: 36927871. DOI: 10.1038/s41598-023-31024-w.
Heilmann, R.M., Csukovich, G., Burgener, I.A., Dengler, F. :
Time to eRAASe chronic inflammation: current advances and future perspectives on renin-angiotensin-aldosterone-system and chronic intestinal inflammation in dogs and humans. Front Vet Sci 10:1180125, 2023. Pubmed reference: 37456955. DOI: 10.3389/fvets.2023.1180125.
Teoh, Y.B., Jiang, J.J., Yamasaki, T., Nagata, N., Sugawara, T., Hasebe, R., Ohta, H., Sasaki, N., Yokoyama, N., Nakamura, K., Kagawa, Y., Takiguchi, M., Murakami, M. :
An inflammatory bowel disease-associated SNP increases local thyroglobulin expression to develop inflammation in miniature dachshunds. Front Vet Sci 10:1192888, 2023. Pubmed reference: 37519997. DOI: 10.3389/fvets.2023.1192888.
Yamasaki, T., Nagata, N., Atsumi, T., Hasebe, R., Tanaka, Y., Ohki, I., Kubota, S., Shinohara, Y., Teoh, Y.B., Yokoyama, N., Sasaki, N., Nakamura, K., Ohta, H., Katsurada, T., Matsuno, Y., Hojyo, S., Hashimoto, S., Takiguchi, M., Murakami, M. :
Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients. Int Immunol , 2023. Pubmed reference: 36933193. DOI: 10.1093/intimm/dxad006.
2022 Galler, A.I., Klavins, K., Burgener, I.A. :
A Preliminary Metabolomic Study of Yorkshire Terrier Enteropathy. Metabolites 12, 2022. Pubmed reference: 35323707. DOI: 10.3390/metabo12030264.
2021 Nakazawa, M., Miyamae, J., Okano, M., Kanemoto, H., Katakura, F., Shiina, T., Ohno, K., Tsujimoto, H., Moritomo, T., Watari, T. :
Dog leukocyte antigen (DLA) class II genotypes associated with chronic enteropathy in French bulldogs and miniature dachshunds. Vet Immunol Immunopathol 237:110271, 2021. Pubmed reference: 34044267. DOI: 10.1016/j.vetimm.2021.110271.
2018 Peiravan, A., Bertolini, F., Rothschild, M.F., Simpson, K.W., Jergens, A.E., Allenspach, K., Werling, D. :
Genome-wide association studies of inflammatory bowel disease in German shepherd dogs. PLoS One 13:e0200685, 2018. Pubmed reference: 30028859. DOI: 10.1371/journal.pone.0200685.
2012 Kathrani, A., Holder, A., Catchpole, B., Alvarez, L., Simpson, K., Werling, D., Allenspach, K. :
TLR5 Risk-Associated Haplotype for Canine Inflammatory Bowel Disease Confers Hyper-Responsiveness to Flagellin. PLoS One 7:e30117, 2012. Pubmed reference: 22279566. DOI: 10.1371/journal.pone.0030117.
2011 Kathrani, A., Werling, D., Allenspach, K. :
Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK. Vet Rec 169:635, 2011. Pubmed reference: 21896567. DOI: 10.1136/vr.d5380.
Kathrani, A., Schmitz, S., Priestnall, S.L., Smith, K.C., Werling, D., Garden, O.A., Allenspach, K. :
CD11c+ cells are significantly decreased in the duodenum, ileum and colon of dogs with inflammatory bowel disease. J Comp Pathol 145:359-66, 2011. Pubmed reference: 21592490. DOI: 10.1016/j.jcpa.2011.03.010.
Kathrani, A., House, A., Catchpole, B., Murphy, A., Werling, D., Allenspach, K. :
Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel disease. Tissue Antigens 78:94-101, 2011. Pubmed reference: 21623734. DOI: 10.1111/j.1399-0039.2011.01707.x.
Maeda, S., Ohno, K., Nakamura, K., Uchida, K., Nakashima, K., Fukushima, K., Tsukamoto, A., Goto-Koshino, Y., Fujino, Y., Tsujimoto, H. :
Quantification of chemokine and chemokine receptor gene expression in duodenal mucosa of dogs with inflammatory bowel disease. Vet Immunol Immunopathol 144:290-8, 2011. Pubmed reference: 21996024. DOI: 10.1016/j.vetimm.2011.08.020.
Malewska, K., Rychlik, A., Nieradka, R., Kander, M. :
Treatment of inflammatory bowel disease (IBD) in dogs and cats. Pol J Vet Sci 14:165-71, 2011. Pubmed reference: 21528730.
Simpson, K.W., Jergens, A.E. :
Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet Clin North Am Small Anim Pract 41:381-98, 2011. Pubmed reference: 21486642. DOI: 10.1016/j.cvsm.2011.02.003.
Smee, N.M., Towell, T.L. :
What is the evidence? Inflammatory bowel disease in a dog. J Am Vet Med Assoc 238:1111-3, 2011. Pubmed reference: 21529230. DOI: 10.2460/javma.238.9.1111.
2010 Cerquetella, M., Spaterna, A., Laus, F., Tesei, B., Rossi, G., Antonelli, E., Villanacci, V., Bassotti, G. :
Inflammatory bowel disease in the dog: differences and similarities with humans. World J Gastroenterol 16:1050-6, 2010. Pubmed reference: 20205273.
Kathrani, A., House, A., Catchpole, B., Murphy, A., German, A., Werling, D., Allenspach, K. :
Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs. PLoS One 5:e15740, 2010. Pubmed reference: 21203467. DOI: 10.1371/journal.pone.0015740.

Edit History


  • Created by Frank Nicholas on 30 Jan 2012
  • Changed by Frank Nicholas on 30 Jan 2012
  • Changed by Imke Tammen2 on 10 Jun 2021
  • Changed by Imke Tammen2 on 19 Sep 2023