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OMIA:001691-9615 : Recombination rate in Canis lupus familiaris (dog)

In other species: Atlantic salmon , Mallard , chicken , domestic cat , horse , pig , taurine cattle , indicine cattle (zebu) , goat , sheep , blackcap , hihi

Categories: Normal phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 612042 (trait)

Mendelian trait/disorder: yes

Disease-related: no

Key variant known: no

Molecular basis: Axelsson et al. (2012) provided evidence that the canine lineage has lost the gene PRDM9, which in other lineages plays a central role in initiating recombination, creating recombination "hotspots". Lacking this gene, the canine lineage has a "greater evolutionary stability of recombination hotspots". Campbell et al. (2016) concluded that despite lacking PRDM9, "dogs have similar broad scale properties of recombination to humans, while fine-scale recombination is similar to other species lacking PRDM9."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:001691-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2016 Campbell, C.L., Bhérer, C., Morrow, B.E., Boyko, A.R., Auton, A. :
A Pedigree-Based Map of Recombination in the Domestic Dog Genome. G3 (Bethesda) 6:3517-3524, 2016. Pubmed reference: 27591755. DOI: 10.1534/g3.116.034678.
2013 Auton, A., Rui Li, Y., Kidd, J., Oliveira, K., Nadel, J., Holloway, J.K., Hayward, J.J., Cohen, P.E., Greally, J.M., Wang, J., Bustamante, C.D., Boyko, A.R. :
Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs. PLoS Genet 9:e1003984, 2013. Pubmed reference: 24348265. DOI: 10.1371/journal.pgen.1003984.
2012 Axelsson, E., Webster, M.T., Ratnakumar, A. :
Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res 22:51-63, 2012. Pubmed reference: 22006216. DOI: 10.1101/gr.124123.111.

Edit History


  • Created by Frank Nicholas on 08 Jun 2012
  • Changed by Frank Nicholas on 05 Aug 2013
  • Changed by Frank Nicholas on 04 Sep 2016