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OMIA:001694-9598 : Resistance/susceptibility to lentivirus in Pan troglodytes

In other species: domestic cat , sheep

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 186940 (gene) , 607750 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2019

Molecular basis: Warren et al. (2019) and Bibollet-Ruche et al. (2019) reported different missense variant that create glycosylation sites in the CD4 molecule, substantially decreasing the chance of lentivirus attachment, and hence infection.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CD4 CD4 molecule Pan troglodytes 12 NC_072410.1 (12621584..12652819) CD4 Homologene, Ensembl , NCBI gene

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2019 Bibollet-Ruche, F., Russell, R.M., Liu, W., Stewart-Jones, G.B.E., Sherrill-Mix, S., Li, Y., Learn, G.H., Smith, A.G., Gondim, M.V.P., Plenderleith, L.J., Decker, J.M., Easlick, J.L., Wetzel, K.S., Collman, R.G., Ding, S., Finzi, A., Ayouba, A., Peeters, M., Leendertz, F.H., van Schijndel, J., Goedmakers, A., Ton, E., Boesch, C., Kuehl, H., Arandjelovic, M., Dieguez, P., Murai, M., Colin, C., Koops, K., Speede, S., Gonder, M.K., Muller, M.N., Sanz, C.M., Morgan, D.B., Atencia, R., Cox, D., Piel, A.K., Stewart, F.A., Ndjango, J.N., Mjungu, D., Lonsdorf, E.V., Pusey, A.E., Kwong, P.D., Sharp, P.M., Shaw, G.M., Hahn, B.H. :
CD4 receptor diversity in chimpanzees protects against SIV infection. Proc Natl Acad Sci U S A :, 2019. Pubmed reference: 30718403 . DOI: 10.1073/pnas.1821197116.
Warren, C.J., Meyerson, N.R., Stabell, A.C., Fattor, W.T., Wilkerson, G.K., Sawyer, S.L., Warren, C.J., Meyerson, N.R., Stabell, A.C., Fattor, W.T., Wilkerson, G.K., Sawyer, S.L. :
A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV). Proc Natl Acad Sci U S A 116:11460-11469, 2019. Pubmed reference: 31113887 . DOI: 10.1073/pnas.1813909116.

Edit History


  • Created by Frank Nicholas on 24 Sep 2019
  • Changed by Frank Nicholas on 24 Sep 2019
  • Changed by Frank Nicholas on 15 May 2020