OMIA 001724-9615 : Melanoma, malignant in Canis lupus familiaris

In other species: lion

Mendelian trait/disorder: unknown

Considered a defect: yes

Inheritance: Genetic pre-disposition to cancer have been described, suggesting that it is a multifactorial disease.

Somatic mutations in the KIT gene have been identified in canine malignant melanomas and such mutations may indicate responsiveness to specific therapeutic interventions. Tani et al. (2021) present such an example of pharmacogenetics, reporting "a canine case of malignant melanoma that responded to toceranib therapy. KIT encoded by KIT harboring a mutation c.1725_1733del is a potential therapeutic target for toceranib in canine malignant melanoma."

Markers: Chu et al. (2012) reported two base substitutions in the canine KIT gene that appeared to be associated with susceptibility to malignant melanoma.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Palma, S.D., McConnell, A., Verganti, S., Starkey, M. :
Review on canine oral melanoma: An undervalued authentic genetic model of human oral melanoma? Vet Pathol 58:881-889, 2021. Pubmed reference: 33685309. DOI: 10.1177/0300985821996658.
Smedley, R.C., Thaiwong, T., Deeth, L.E., Kiupel, M. :
Correlation between KIT expression and c-Kit mutations in 2 subtypes of canine oral melanocytic neoplasms. Vet Pathol :3009858211009784, 2021. Pubmed reference: 33910439. DOI: 10.1177/03009858211009784.
Tani, H., Miyamoto, R., Noguchi, S., Kurita, S., Nagashima, T., Michishita, M., Yayoshi, N., Tamura, K., Bonkobara, M. :
A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis. BMC Vet Res 17:147, 2021. Pubmed reference: 33827546. DOI: 10.1186/s12917-021-02864-3.
2019 Prouteau, A., André, C. :
Canine melanomas as models for human melanomas: Clinical, histological, and genetic comparison. Genes (Basel) 10:, 2019. Pubmed reference: 31262050. DOI: 10.3390/genes10070501.
2018 Jama, N., Farquhar, N., Butt, Z., Coupland, S.E., Sacco, J.J., Scase, T., Fielding, A.B., Coulson, J.M., Kalirai, H., Killick, D.R. :
Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma. J Comp Pathol 162:50-58, 2018. Pubmed reference: 30060843. DOI: 10.1016/j.jcpa.2018.06.007.
2016 Gramer, I., Kessler, M., Geyer, J. :
Detection of novel polymorphisms in the ckit gene of canine patients with lymphoma, melanoma, haemangiosarcoma, and osteosarcoma. Vet Res Commun 40:89-95, 2016. Pubmed reference: 26971271. DOI: 10.1007/s11259-016-9653-x.
2013 Chu, P.Y., Pan, S.L., Liu, C.H., Lee, J., Yeh, L.S., Liao, A.T. :
KIT gene exon 11 mutations in canine malignant melanoma. Vet J 196:226-30, 2013. Pubmed reference: 23069279. DOI: 10.1016/j.tvjl.2012.09.005.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
2011 Murakami, A., Mori, T., Sakai, H., Murakami, M., Yanai, T., Hoshino, Y., Maruo, K. :
Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas. Vet Comp Oncol 9:219-24, 2011. Pubmed reference: 21848624. DOI: 10.1111/j.1476-5829.2010.00253.x.
2009 London, C.A., Malpas, P.B., Wood-Follis, S.L., Boucher, J.F., Rusk, A.W., Rosenberg, M.P., Henry, C.J., Mitchener, K.L., Klein, M.K., Hintermeister, J.G., Bergman, P.J., Couto, G.C., Mauldin, G.N., Michels, G.M. :
Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clin Cancer Res 15:3856-65, 2009. Pubmed reference: 19470739. DOI: 10.1158/1078-0432.CCR-08-1860.
2003 Sulaimon, S.S., Kitchell, B.E. :
The basic biology of malignant melanoma: molecular mechanisms of disease progression and comparative aspects. J Vet Intern Med 17:760-72, 2003. Pubmed reference: 14658711.
1992 Mayr, B., Eschborn, U., Schleger, W., Loupal, G., Burtscher, H. :
Cytogenetic studies in a canine malignant melanoma. J Comp Pathol 106:319-22, 1992. Pubmed reference: 1602064.

Edit History

  • Created by Frank Nicholas on 18 Oct 2012
  • Changed by Frank Nicholas on 18 Oct 2012
  • Changed by Imke Tammen2 on 14 Apr 2021
  • Changed by Imke Tammen2 on 15 Apr 2021
  • Changed by Imke Tammen2 on 27 Aug 2021