OMIA 001724-9615 : Melanoma, malignant in Canis lupus familiaris

Mendelian trait/disorder: unknown

Considered a defect: yes

Markers: Chu et al. (2012) reported two base substitutions in the canine KIT gene that appeared to be associated with susceptibility to malignant melanoma.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 Jama, N., Farquhar, N., Butt, Z., Coupland, S.E., Sacco, J.J., Scase, T., Fielding, A.B., Coulson, J.M., Kalirai, H., Killick, D.R. :
Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma. J Comp Pathol 162:50-58, 2018. Pubmed reference: 30060843. DOI: 10.1016/j.jcpa.2018.06.007.
2013 Chu, P.Y., Pan, S.L., Liu, C.H., Lee, J., Yeh, L.S., Liao, A.T. :
KIT gene exon 11 mutations in canine malignant melanoma. Vet J 196:226-30, 2013. Pubmed reference: 23069279. DOI: 10.1016/j.tvjl.2012.09.005.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
2003 Sulaimon, S.S., Kitchell, B.E. :
The basic biology of malignant melanoma: molecular mechanisms of disease progression and comparative aspects. J Vet Intern Med 17:760-72, 2003. Pubmed reference: 14658711.
1992 Mayr, B., Eschborn, U., Schleger, W., Loupal, G., Burtscher, H. :
Cytogenetic studies in a canine malignant melanoma. J Comp Pathol 106:319-22, 1992. Pubmed reference: 1602064.

Edit History

  • Created by Frank Nicholas on 18 Oct 2012
  • Changed by Frank Nicholas on 18 Oct 2012