OMIA:001724-9615 : Melanoma, malignant in Canis lupus familiaris (dog)

In other species: swordtail and platyfish , Japanese medaka , lion , water buffalo

Categories: Neoplasm

Mendelian trait/disorder: unknown

Considered a defect: yes

Inheritance: Genetic pre-disposition to cancer have been described, suggesting that it is a multifactorial disease. Somatic mutations in the KIT gene have been identified in canine malignant melanomas and such mutations may indicate responsiveness to specific therapeutic interventions. Tani et al. (2021) present such an example of pharmacogenetics, reporting "a canine case of malignant melanoma that responded to toceranib therapy. KIT encoded by KIT harboring a mutation c.1725_1733del is a potential therapeutic target for toceranib in canine malignant melanoma."

Markers: Chu et al. (2012) reported two base substitutions in the canine KIT gene that appeared to be associated with susceptibility to malignant melanoma.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001724-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Contel, I.J., Fonseca-Alves, C.E., Ferrari, H.F., Laufer-Amorim, R., Xavier-Júnior, J.C.C. :
Review of the comparative pathological and immunohistochemical features of human and canine cutaneous melanocytic neoplasms. J Comp Pathol 211:S0021-9975(24)00245-7:26-35, 2024. Pubmed reference: 38761560. DOI: 10.1016/j.jcpa.2024.04.001.
Cronise, K.E., Coy, J., Dow, S., Hauck, M.L., Regan, D.P. :
Immunohistochemical and transcriptomic characterization of T and myeloid cell infiltrates in canine malignant melanoma. Vet Comp Oncol , 2024. Pubmed reference: 38752589. DOI: 10.1111/vco.12981.
Hasan, M.N., Rahman, M.M., Husna, A.A., Arif, M., Jasineviciute, I., Kato, D., Nakagawa, T., Miura, N. :
Upregulation and functional roles of miR-450b in canine oral melanoma. Noncoding RNA Res 9:376-387, 2024. Pubmed reference: 38511062. DOI: 10.1016/j.ncrna.2024.01.017.
Polton, G., Borrego, J.F., Clemente-Vicario, F., Clifford, C.A., Jagielski, D., Kessler, M., Kobayashi, T., Lanore, D., Queiroga, F.L., Rowe, A.T., Vajdovich, P., Bergman, P.J. :
Melanoma of the dog and cat: consensus and guidelines. Front Vet Sci 11:1359426, 2024. Pubmed reference: 38645640. DOI: 10.3389/fvets.2024.1359426.
2023 Hritcu, O.M., Bocaneti Daraban, F., Bacusca, F.D., Pasca, A.S. :
Unusual canine cutaneous melanoma presenting parietal bone metastasis: A case report. Vet Sci 10:282, 2023. Pubmed reference: 37104437. DOI: 10.3390/vetsci10040282.
Koo, K., Wuenschmann, A., Rendahl, A., Song, K.Y., Forster, C., Wolf-Ringwall, A., Borgatti, A., Giubellino, A. :
Expression and prognostic evaluation of the receptor tyrosine kinase MET in canine malignant melanoma. Vet Sci 10:249, 2023. Pubmed reference: 37104404. DOI: 10.3390/vetsci10040249.
Oh, J.H., Cho, J.Y. :
Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3.
Pisamai, S., Edwards, S.W., Cheng, C.W., Chaivichit, P., Sooksiri, M., Yanakam, S., Maneewong, S., Suriyaphol, G. :
Tissue transcriptome profiling and pathway analyses revealed novel potential biomarkers in the tumor progression of canine oral melanoma. Res Vet Sci 165:105036, 2023. Pubmed reference: 37856944. DOI: 10.1016/j.rvsc.2023.105036.
Vanhaezebrouck, I.F., Bakhle, K.M., Mendez-Valenzuela, C.R., Lyle, L.T., Konradt, K., Scarpelli, M.L. :
Single institution study of the immune landscape for canine oral melanoma based on transcriptome analysis of the primary tumor. Front Vet Sci 10:1285909, 2023. Pubmed reference: 38260202. DOI: 10.3389/fvets.2023.1285909.
Yamamoto, M., Fujiwara, N. :
Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells. J Vet Med Sci , 2023. Pubmed reference: 37495516. DOI: 10.1292/jvms.23-0274.
2022 Stevenson, V.B., Klahn, S., LeRoith, T., Huckle, W.R. :
Canine melanoma: A review of diagnostics and comparative mechanisms of disease and immunotolerance in the era of the immunotherapies. Front Vet Sci 9:1046636, 2022. Pubmed reference: 36686160. DOI: 10.3389/fvets.2022.1046636.
2021 Palma, S.D., McConnell, A., Verganti, S., Starkey, M. :
Review on canine oral melanoma: An undervalued authentic genetic model of human oral melanoma? Vet Pathol 58:881-889, 2021. Pubmed reference: 33685309. DOI: 10.1177/0300985821996658.
Smedley, R.C., Thaiwong, T., Deeth, L.E., Kiupel, M. :
Correlation between KIT expression and c-Kit mutations in 2 subtypes of canine oral melanocytic neoplasms. Vet Pathol :3009858211009784, 2021. Pubmed reference: 33910439. DOI: 10.1177/03009858211009784.
Tani, H., Miyamoto, R., Noguchi, S., Kurita, S., Nagashima, T., Michishita, M., Yayoshi, N., Tamura, K., Bonkobara, M. :
A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis. BMC Vet Res 17:147, 2021. Pubmed reference: 33827546. DOI: 10.1186/s12917-021-02864-3.
2019 Prouteau, A., André, C. :
Canine melanomas as models for human melanomas: Clinical, histological, and genetic comparison. Genes (Basel) 10, 2019. Pubmed reference: 31262050. DOI: 10.3390/genes10070501.
Wong, K., van der Weyden, L., Schott, C.R., Foote, A., Constantino-Casas, F., Smith, S., Dobson, J.M., Murchison, E.P., Wu, H., Yeh, I., Fullen, D.R., Joseph, N., Bastian, B.C., Patel, R.M., Martincorena, I., Robles-Espinoza, C.D., Iyer, V., Kuijjer, M.L., Arends, M.J., Brenn, T., Harms, P.W., Wood, G.A., Adams, D.J. :
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma. Nat Commun 10:353, 2019. Pubmed reference: 30664638. DOI: 10.1038/s41467-018-08081-1.
2018 Jama, N., Farquhar, N., Butt, Z., Coupland, S.E., Sacco, J.J., Scase, T., Fielding, A.B., Coulson, J.M., Kalirai, H., Killick, D.R. :
Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma. J Comp Pathol 162:50-58, 2018. Pubmed reference: 30060843. DOI: 10.1016/j.jcpa.2018.06.007.
2016 Gramer, I., Kessler, M., Geyer, J. :
Detection of novel polymorphisms in the ckit gene of canine patients with lymphoma, melanoma, haemangiosarcoma, and osteosarcoma. Vet Res Commun 40:89-95, 2016. Pubmed reference: 26971271. DOI: 10.1007/s11259-016-9653-x.
2013 Chu, P.Y., Pan, S.L., Liu, C.H., Lee, J., Yeh, L.S., Liao, A.T. :
KIT gene exon 11 mutations in canine malignant melanoma. Vet J 196:226-30, 2013. Pubmed reference: 23069279. DOI: 10.1016/j.tvjl.2012.09.005.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
2011 Murakami, A., Mori, T., Sakai, H., Murakami, M., Yanai, T., Hoshino, Y., Maruo, K. :
Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas. Vet Comp Oncol 9:219-24, 2011. Pubmed reference: 21848624. DOI: 10.1111/j.1476-5829.2010.00253.x.
2009 London, C.A., Malpas, P.B., Wood-Follis, S.L., Boucher, J.F., Rusk, A.W., Rosenberg, M.P., Henry, C.J., Mitchener, K.L., Klein, M.K., Hintermeister, J.G., Bergman, P.J., Couto, G.C., Mauldin, G.N., Michels, G.M. :
Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clin Cancer Res 15:3856-65, 2009. Pubmed reference: 19470739. DOI: 10.1158/1078-0432.CCR-08-1860.
2003 Sulaimon, S.S., Kitchell, B.E. :
The basic biology of malignant melanoma: molecular mechanisms of disease progression and comparative aspects. J Vet Intern Med 17:760-72, 2003. Pubmed reference: 14658711.
1992 Mayr, B., Eschborn, U., Schleger, W., Loupal, G., Burtscher, H. :
Cytogenetic studies in a canine malignant melanoma. J Comp Pathol 106:319-22, 1992. Pubmed reference: 1602064.

Edit History


  • Created by Frank Nicholas on 18 Oct 2012
  • Changed by Frank Nicholas on 18 Oct 2012
  • Changed by Imke Tammen2 on 14 Apr 2021
  • Changed by Imke Tammen2 on 15 Apr 2021
  • Changed by Imke Tammen2 on 27 Aug 2021
  • Changed by Imke Tammen2 on 01 Feb 2023