OMIA:001725-7959 : Resistance/susceptibility to grass carp reovirus in Ctenopharyngodon idella (grass carp) |
Categories: Immune system phene
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal dominant
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2012
Inheritance: As reported by Wan et al. (2012): "The cumulative mortality in genotype AA (40.70%) and AB (52.73%) was significantly lower than that in genotype BB (71.43%) (P = 0.032). The result demonstrated that genotype AA and AB were resistant to GCRV, while genotype BB was susceptible."
Molecular basis: By sequencing a key candidate gene (a receptor for a range of viruses), Wan et al. (2012) discovered that resistance to grass carp reovirus is due to a 15-bp deletion in the coding region of the Ctenopharyngodon idella Retinoic acid-inducible gene I (CiRIG-I). As the authors reported: "The deletion mutation cancels a predicted phosphorylation site and changes the secondary structure and the probability of peroxisomal targeting signal 1 in CiRIG-I."
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| CiRIG-I | Ctenopharyngodon idella | - | no genomic information (-..-) | CiRIG-I | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001725-7959: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2012 | Wan, Q., Su, J., Wang, L., Chen, L., Chen, X. : |
| A 15 nucleotide deletion mutation in coding region of the RIG-I lowers grass carp (Ctenopharyngodon idella) resistance to grass carp reovirus. Fish Shellfish Immunol 33:442-7, 2012. Pubmed reference: 22626563. DOI: 10.1016/j.fsi.2012.05.010. |
Edit History
- Created by Frank Nicholas on 21 Oct 2012
- Changed by Frank Nicholas on 21 Oct 2012
- Changed by Frank Nicholas on 15 May 2020
- Changed by Imke Tammen2 on 16 Oct 2023