OMIA 001725-7959 : Resistance to grass carp reovirus in Ctenopharyngodon idella

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2012

Inheritance: As reported by Wan et al. (2012): "The cumulative mortality in genotype AA (40.70%) and AB (52.73%) was significantly lower than that in genotype BB (71.43%) (P = 0.032). The result demonstrated that genotype AA and AB were resistant to GCRV, while genotype BB was susceptible."

Molecular basis: By sequencing a key candidate gene (a receptor for a range of viruses), Wan et al. (2012) discovered that resistance to grass carp reovirus is due to a 15-bp deletion in the coding region of the Ctenopharyngodon idella Retinoic acid-inducible gene I (CiRIG-I). As the authors reported: "The deletion mutation cancels a predicted phosphorylation site and changes the secondary structure and the probability of peroxisomal targeting signal 1 in CiRIG-I."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CiRIG-I Ctenopharyngodon idella - no genomic information (-..-) CiRIG-I Ensembl

Reference


2012 Wan, Q., Su, J., Wang, L., Chen, L., Chen, X. :
A 15 nucleotide deletion mutation in coding region of the RIG-I lowers grass carp (Ctenopharyngodon idella) resistance to grass carp reovirus. Fish Shellfish Immunol 33:442-7, 2012. Pubmed reference: 22626563. DOI: 10.1016/j.fsi.2012.05.010.

Edit History


  • Created by Frank Nicholas on 21 Oct 2012
  • Changed by Frank Nicholas on 21 Oct 2012