OMIA:001780-9615 : Blood group system/dog erythrocyte antigen (DEA) 4 in Canis lupus familiaris (dog)

Categories: Haematopoietic system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: no

Key variant known: no

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars.

Species-specific name: Previously known as Blood Group System C, or canine erythrocyte antigen (CEA) 4

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: As reported by Hale (1995): "A dog possessing DEA 4 and no other antigen is considered a "universal" donors."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001780-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Mangiaterra, S., Rossi, G., Antognoni, M.T., Cerquetella, M., Marchegiani, A., Miglio, A., Gavazza, A. :
Canine blood group prevalence and geographical distribution around the world: An updated systematic review. Animals (Basel) 11, 2021. Pubmed reference: 33572864. DOI: 10.3390/ani11020342.
2020 Ebelt, A.K., Fuchs, S., Weber, C., Müller, E., Giger, U. :
Survey of blood groups DEA 1, DEA 4, DEA 5, Dal, and Kai 1/Kai 2 in different canine breeds from a diagnostic laboratory in Germany. Front Vet Sci 7:85, 2020. Pubmed reference: 32185185. DOI: 10.3389/fvets.2020.00085.
2019 Zaremba, R., Brooks, A., Thomovsky, E. :
Transfusion medicine: An update on antigens, antibodies and serologic testing in dogs and cats. Top Companion Anim Med 34:36-46, 2019. Pubmed reference: 30808496. DOI: 10.1053/j.tcam.2018.12.005.
2016 Euler, C.C., Lee, J.H., Kim, H.Y., Raj, K., Mizukami, K., Giger, U. :
Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America. J Vet Intern Med 30:1642-1647, 2016. Pubmed reference: 27627791. DOI: 10.1111/jvim.14572.
Spada, E., Proverbio, D., Viñals Flórez, L.M., Serra Gómez de la Serna, B., Del Rosario Perlado Chamizo, M., Baggiani, L., Perego, R. :
Prevalence of Dog Erythrocyte Antigens 1, 4, and 7 in Podenco Ibicenco (Ibizan Hounds) from Ibiza Island. Vet Med Int 2016:1048257, 2016. Pubmed reference: 27034890. DOI: 10.1155/2016/1048257.
2015 Spada, E., Proverbio, D., Viñals Flórez, L.M., Del Rosario Perlado Chamizo, M., Perego, R., Bagnagatti De Giorgi, G., Baggiani, L. :
Prevalence of dog erythrocyte antigens 1, 4, and 7 in galgos (Spanish Greyhounds). J Vet Diagn Invest 27:558-61, 2015. Pubmed reference: 26179093. DOI: 10.1177/1040638715592025.
2010 Kessler, RJ., Reese, J., Chang, D., Seth, M., Hale, AS., Giger, U. :
Dog erythrocyte antigens 1.1, 1.2, 3, 4, 7, and Dal blood typing and cross-matching by gel column technique. Vet Clin Pathol , 2010. Pubmed reference: 20727123. DOI: 10.1111/j.1939-165X.2010.00249.x.
2005 Giger, U., Stieger, K., Palos, H. :
Comparison of various canine blood-typing methods. Am J Vet Res 66:1386-92, 2005. Pubmed reference: 16173482.
2003 Melzer, K.J., Wardrop, K.J., Hale, A.S., Wong, V.M. :
A hemolytic transfusion reaction due to DEA 4 alloantibodies in a dog. J Vet Intern Med 17:931-3, 2003. Pubmed reference: 14658734.
1997 Corato, A., Mazza, G., Hale, A.S., Barker, R.N., Day, M.J. :
Biochemical characterization of canine blood group antigens: immunoprecipitation of DEA 1.2, 4 and 7 and identification of a dog erythrocyte membrane antigen homologous to human Rhesus. Vet Immunol Immunopathol 59:213-23, 1997. Pubmed reference: 9477473.
1995 Hale, AS. :
Canine blood groups and their importance in veterinary transfusion medicine. Vet Clin North Am Small Anim Pract 25:1323-32, 1995. Pubmed reference: 8619269.
Usui, R., Hirota, J., Oyamada, T., Ikemoto, S. :
Differences of phenotype and gene frequency by C system in canine species - Note Journal of Veterinary Medical Science 57:379-380, 1995. Pubmed reference: 7492670.

Edit History

  • Created by Frank Nicholas on 17 Apr 2013
  • Changed by Frank Nicholas on 17 Apr 2013