OMIA:001790-9615 : Chondrodysplasia, Labrador in Canis lupus familiaris
Categories: Skeleton phene (incl. short stature & teeth)
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 132400 (trait) , 183900 (trait) , 108300 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: yes
Key variant known: no
Inheritance: A segregation analysis conducted by Smit et al. (2011) provided evidence for autosomal recessive inheritance.
Markers: Using the comparative positional candidate gene strategy, Smit et al. (2011) investigated 8 candidate genes from three potential human homologous disorders (see MIM numbers above) in 8 affected and 14 related normal dogs, but could not find a causal mutation.
|2011||Smit, JJ., Temwitchitr, J., Brocks, BA., Nikkels, PG., Hazewinkel, HA., Leegwater, PA. :|
|Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers. Vet J 187:269-71, 2011. Pubmed reference: 20018534 . DOI: 10.1016/j.tvjl.2009.11.009.|
- Changed by Frank Nicholas on 23 Apr 2013
- Created by Frank Nicholas on 23 Apr 2013