OMIA 001790-9615 : Chondrodysplasia, Labrador in Canis lupus familiaris |
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
132400 (trait)
,
183900 (trait)
,
108300 (trait)
Mendelian trait/disorder:
yes
Mode of inheritance:
Autosomal Recessive
Considered a defect:
yes
Key variant known:
no
Inheritance:
A segregation analysis conducted by Smit et al. (2011) provided evidence for autosomal recessive inheritance.
Markers:
Using the comparative positional candidate gene strategy, Smit et al. (2011) investigated 8 candidate genes from three potential human homologous disorders (see MIM numbers above) in 8 affected and 14 related normal dogs, but could not find a causal mutation.
Breed:
Labrador.
Reference
2011 | Smit, JJ., Temwitchitr, J., Brocks, BA., Nikkels, PG., Hazewinkel, HA., Leegwater, PA. : | |
Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers. Vet J 187:269-71, 2011. Pubmed reference: 20018534. DOI: 10.1016/j.tvjl.2009.11.009. |
Edit History
- Created by Frank Nicholas on 23 Apr 2013
- Changed by Frank Nicholas on 23 Apr 2013