OMIA:001791-9615 : Intestinal cobalamin (vitamin B12) malabsorption, generic in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 261100 (trait) , 618882 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: similar to: Imerslund-Gräsbeck syndrome (IGS1) (selective cobalamin malabsorption; megaloblastic anemia 1 (MGA1)) and Imerslund-Gräsbeck syndrome 2; IGS2

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001791-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Kather, S., Grützner, N., Kook, P.H., Dengler, F., Heilmann, R.M. :
Review of cobalamin status and disorders of cobalamin metabolism in dogs. J Vet Intern Med 34:13-28, 2020. Pubmed reference: 31758868. DOI: 10.1111/jvim.15638.
2015 McLauchlan, G., McLaughlin, A., Sewell, A.C., Bell, R. :
Methylmalonic aciduria secondary to selective cobalamin malabsorption in a Yorkshire Terrier. J Am Anim Hosp Assoc 51:285-8, 2015. Pubmed reference: 26083440. DOI: 10.5326/JAAHA-MS-6195.
2013 Dandrieux, J.R., Noble, P.J., Halladay, L.J., McLean, L., German, A.J. :
Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey. J Small Anim Pract 54:143-8, 2013. Pubmed reference: 23458644. DOI: 10.1111/jsap.12039.
Grützner, N., Heilmann, R.M., Bridges, C.S., Suchodolski, J.S., Steiner, J.M. :
Serum concentrations of canine alpha(1)-proteinase inhibitor in cobalamin-deficient Yorkshire Terrier dogs. J Vet Diagn Invest 25:376-85, 2013. Pubmed reference: 23604260. DOI: 10.1177/1040638713485960.
Grützner, N., Heilmann, R.M., Stupka, K.C., Rangachari, V.R., Weber, K., Holzenburg, A., Suchodolski, J.S., Steiner, J.M. :
Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency. Vet J 197:420-6, 2013. Pubmed reference: 23499543. DOI: 10.1016/j.tvjl.2013.02.002.
Grützner, N., Bishop, M.A., Suchodolski, J.S., Steiner, J.M. :
Evaluation of the MYC_CANFA gene in Chinese Shar Peis with cobalamin deficiency. Vet Clin Pathol 42:61-5, 2013. Pubmed reference: 23278253. DOI: 10.1111/vcp.12010.
Kook, P.H. :
Cobalamin deficiency states: a fine example of the One Medicine concept. Vet J 196:137-8, 2013. Pubmed reference: 23642465. DOI: 10.1016/j.tvjl.2013.03.022.
Lutz, S., Sewell, A.C., Reusch, C.E., Kook, P.H. :
Clinical and laboratory findings in Border Collies with presumed hereditary juvenile cobalamin deficiency Journal of the American Animal Hospital Association 49:197-203, 2013.
Rossi, G., Breda, S., Giordano, A., Pengo, G., Dall'Ara, P., Rossi, G., Bo, S., Paltrinieri, S. :
Association between hypocobalaminaemia and hyperhomocysteinaemia in dogs. Vet Rec 172:365, 2013. Pubmed reference: 23396527. DOI: 10.1136/vr.101171.
2012 Bishop, M.A., Xenoulis, P.G., Berghoff, N., Grützner, N., Suchodolski, J.S., Steiner, J.M. :
Partial characterization of cobalamin deficiency in Chinese Shar Peis. Vet J 191:41-5, 2012. Pubmed reference: 21652239. DOI: 10.1016/j.tvjl.2011.05.008.
2010 Grützner, N., Bishop, M.A., Suchodolski, J.S., Steiner, J.M. :
Association study of cobalamin deficiency in the Chinese Shar Pei. J Hered 101:211-7, 2010. Pubmed reference: 19926684. DOI: 10.1093/jhered/esp100.

Edit History

  • Created by Frank Nicholas on 13 May 2013