OMIA 001794-9940 : Cystic fibrosis in Ovis aries

In other species: domestic ferret , pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 219700 (trait) , 602421 (gene)

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific description: Fan et al. (2018) "describe the generation of a sheep model for CF using CRISPR/Cas9 genome editing and somatic cell nuclear transfer (SCNT) techniques." (Genetically-modifed organism; GMO)


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Menchaca, A., Dos Santos-Neto, P.C., Mulet, A.P., Crispo, M. :
CRISPR in livestock: From editing to printing. Theriogenology 150:247-254, 2020. Pubmed reference: 32088034. DOI: 10.1016/j.theriogenology.2020.01.063.
2018 Fan, Z., Perisse, I.V., Cotton, C.U., Regouski, M., Meng, Q., Domb, C., Van Wettere, A.J., Wang, Z., Harris, A., White, K.L., Polejaeva, I.A. :
A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene. JCI Insight 3:, 2018. Pubmed reference: 30282831. DOI: 10.1172/jci.insight.123529.

Edit History

  • Created by Imke Tammen2 on 19 Apr 2021