OMIA 001797-9615 : Mast cell tumour in Canis lupus familiaris

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Markers: Biasoli et al. (2019) reported a "SNP rs850678541 (CFA31:34760750) represents a G>A transition (plus DNA strand) located in exon 16 of the canine DSCAM gene, which encodes a cell adhesion molecule. It occurs in the third base of a codon (representing arginine), and, as such, is a synonymous mutation (changing the codon from CGC to CGT)" that is associated with mast cell tumors in Golden and Labrador Retirevers.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Biasoli, D., Compston-Garnett, L., Ricketts, S.L., Birand, Z., Courtay-Cahen, C., Fineberg, E., Arendt, M., Boerkamp, K., Melin, M., Koltookian, M., Murphy, S., Rutteman, G., Lindblad-Toh, K., Starkey, M. :
A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers. PLoS Genet 15:e1007967, 2019. Pubmed reference: 30901340. DOI: 10.1371/journal.pgen.1007967.
Vozdova, M., Kubickova, S., Fictum, P., Fröhlich, J., Jelinek, F., Rubes, J. :
Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours. Vet J 247:71-74, 2019. Pubmed reference: 30971355. DOI: 10.1016/j.tvjl.2019.03.005.
2015 Arendt, M.L., Melin, M., Tonomura, N., Koltookian, M., Courtay-Cahen, C., Flindall, N., Bass, J., Boerkamp, K., Megquir, K., Youell, L., Murphy, S., McCarthy, C., London, C., Rutteman, G.R., Starkey, M., Lindblad-Toh, K. :
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours. PLoS Genet 11:e1005647, 2015. Pubmed reference: 26588071. DOI: 10.1371/journal.pgen.1005647.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
Warland, J., Dobson, J. :
Breed predispositions in canine mast cell tumour: A single centre experience in the United Kingdom. Vet J :, 2013. Pubmed reference: 23583004. DOI: 10.1016/j.tvjl.2013.02.017.

Edit History


  • Created by Frank Nicholas on 03 May 2013
  • Changed by Frank Nicholas on 06 Aug 2016
  • Changed by Frank Nicholas on 06 Apr 2019