OMIA:001797-9615 : Mast cell tumour in Canis lupus familiaris (dog)

Categories: Neoplasm

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Markers: Biasoli et al. (2019) reported a "SNP rs850678541 (CFA31:34760750) represents a G>A transition (plus DNA strand) located in exon 16 of the canine DSCAM gene, which encodes a cell adhesion molecule. It occurs in the third base of a codon (representing arginine), and, as such, is a synonymous mutation (changing the codon from CGC to CGT)" that is associated with mast cell tumors in Golden and Labrador Retirevers.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001797-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Zmorzynski, S., Kimicka-Szajwaj, A., Szajwaj, A., Czerwik-Marcinkowska, J., Wojcierowski, J. :
Genetic changes in mastocytes and their significance in mast cell tumor prognosis and treatment. Genes (Basel) 15:137, 2024. Pubmed reference: 38275618. DOI: 10.3390/genes15010137.
2023 Burge, R., Woolard, K.D., Willcox, J.L., Rebhun, R.B., Burton, J.H., Al-Nadaf, S., Skorupski, K.A. :
High-grade, stage 2 mast cell tumors: Outcome in dogs with local and systemic therapy. J Am Anim Hosp Assoc 59:167-176, 2023. Pubmed reference: 37432790. DOI: 10.5326/JAAHA-MS-7319.
Cherzan, N.L., Fryer, K., Burke, B., Farrelly, J. :
Factors affecting prognosis in canine subcutaneous mast cell tumors: 45 cases. Vet Surg , 2023. Pubmed reference: 36788161. DOI: 10.1111/vsu.13944.
Coelho, Y.N.B., Soldi, L.R., da Silva, P.H.R., Mesquita, C.M., Paranhos, L.R., Dos Santos, T.R., Silva, M.J.B. :
Tyrosine kinase inhibitors as an alternative treatment in canine mast cell tumor. Front Vet Sci 10:1188795, 2023. Pubmed reference: 37360406. DOI: 10.3389/fvets.2023.1188795.
Conrad, D., Kehl, A., Müller, T., Klopfleisch, R., Aupperle-Lellbach, H. :
Immunohistochemical and molecular genetic analysis of canine digital mast cell tumours. Animals (Basel) 13, 2023. Pubmed reference: 37238124. DOI: 10.3390/ani13101694.
Joselevitch, J.A., Vargas, T.H.M., Pulz, L.H., Cadrobbi, K.G., Huete, G.C., Nishiya, A.T., Kleeb, S.R., Xavier, J.G., Strefezzi, R.F. :
High lysyl oxidase expression is an indicator of poor prognosis in dogs with cutaneous mast cell tumours. Vet Comp Oncol , 2023. Pubmed reference: 37186079. DOI: 10.1111/vco.12898.
Ledur, G.R., Trindade-Gerardi, A.B., Pavarini, S.P., de Oliveira, L.O., Dos Santos, K.H.S., Ferreiro, L., Gerardi, D.G. :
Presence of gastrointestinal paraneoplastic syndrome at diagnosis in dogs with cutaneous mast cell tumors and its influence on disease-free interval and survival. Top Companion Anim Med :100808, 2023. Pubmed reference: 37648020. DOI: 10.1016/j.tcam.2023.100808.
Marconato, L., Stefanello, D., Solari Basano, F., Faroni, E., Dacasto, M., Giantin, M., Bettini, G., Aresu, L., Bonfanti, U., Bertazzolo, W., Annoni, M., Lecchi, C., Sabattini, S. :
Subcutaneous mast cell tumours: A prospective multi-institutional clinicopathological and prognostic study of 43 dogs. Vet Rec :e2991, 2023. Pubmed reference: 37224084. DOI: 10.1002/vetr.2991.
Peaston, A. :
What clinicopathological factors predict prognosis for canine subcutaneous mast cell tumours? Vet Rec 193:31-33, 2023. Pubmed reference: 37417510. DOI: 10.1002/vetr.3237.
Rodríguez, J., Santana, Á., Borzollino, M.A., Herráez, P., Killick, D.R., de Los Monteros, A.E. :
Epidemiology of canine cutaneous round cell tumours on the canary archipelago in Spain. Vet Comp Oncol 21:406-418, 2023. Pubmed reference: 37143410. DOI: 10.1111/vco.12899.
Syed, S., Knight, B.J., Wood, G.A., Coomber, B.L. :
Prognostic value of epigenetic markers for canine mast cell cancer. PLoS One 18:e0283616, 2023. Pubmed reference: 36996057. DOI: 10.1371/journal.pone.0283616.
Yang, C., Bradley, C.W., Preziosi, D., Mauldin, E.A. :
Cutaneous mastocytosis in 8 young dogs and review of literature. Vet Pathol :3009858231174452, 2023. Pubmed reference: 37222130. DOI: 10.1177/03009858231174452.
2021 Abrams, B.E., Putterman, A.B., Ruple, A., Wavreille, V., Selmic, L.E. :
Variability in tumor margin reporting for soft tissue sarcoma and cutaneous mast cell tumors in dogs: A systematic review. Vet Surg 50:259-272, 2021. Pubmed reference: 33331059. DOI: 10.1111/vsu.13539.
Hédan, B., Cadieu, É., Rimbault, M., Vaysse, A., Dufaure de Citres, C., Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., Derrien, T., André, C. :
Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLoS Genet 17:e1009395, 2021. Pubmed reference: 33793571. DOI: 10.1371/journal.pgen.1009395.
2019 Biasoli, D., Compston-Garnett, L., Ricketts, S.L., Birand, Z., Courtay-Cahen, C., Fineberg, E., Arendt, M., Boerkamp, K., Melin, M., Koltookian, M., Murphy, S., Rutteman, G., Lindblad-Toh, K., Starkey, M. :
A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers. PLoS Genet 15:e1007967, 2019. Pubmed reference: 30901340. DOI: 10.1371/journal.pgen.1007967.
Thamm, D.H., Avery, A.C., Berlato, D., Bulman-Fleming, J., Clifford, C.A., Hershey, A.E., Intile, J.L., Jones, P.D., Kamstock, D.A., Liptak, J.M., Pavuk, A., Peauroi, J., Powell, R., Rissetto, K., Valli, V.E.O., Webster, J.D. :
Prognostic and predictive significance of KIT protein expression and c-kit gene mutation in canine cutaneous mast cell tumours: A consensus of the Oncology-Pathology Working Group. Vet Comp Oncol , 2019. Pubmed reference: 31264352. DOI: 10.1111/vco.12518.
Vozdova, M., Kubickova, S., Fictum, P., Fröhlich, J., Jelinek, F., Rubes, J. :
Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours. Vet J 247:71-74, 2019. Pubmed reference: 30971355. DOI: 10.1016/j.tvjl.2019.03.005.
2015 Arendt, M.L., Melin, M., Tonomura, N., Koltookian, M., Courtay-Cahen, C., Flindall, N., Bass, J., Boerkamp, K., Megquir, K., Youell, L., Murphy, S., McCarthy, C., London, C., Rutteman, G.R., Starkey, M., Lindblad-Toh, K. :
Genome-wide association study of Golden Retrievers identifies germ-line risk factors predisposing to mast cell tumours. PLoS Genet 11:e1005647, 2015. Pubmed reference: 26588071. DOI: 10.1371/journal.pgen.1005647.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
Warland, J., Dobson, J. :
Breed predispositions in canine mast cell tumour: A single centre experience in the United Kingdom. Vet J , 2013. Pubmed reference: 23583004. DOI: 10.1016/j.tvjl.2013.02.017.
2006 Webster, J.D., Yuzbasiyan-Gurkan, V., Kaneene, J.B., Miller, R., Resau, J.H., Kiupel, M. :
The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumors. Neoplasia 8:104-11, 2006. Pubmed reference: 16611403. DOI: 10.1593/neo.05622.
2004 Misdorp, W. :
Mast cells and canine mast cell tumours. A review. Vet Q 26:156-69, 2004. Pubmed reference: 15663212. DOI: 10.1080/01652176.2004.9695178.

Edit History


  • Created by Frank Nicholas on 03 May 2013
  • Changed by Frank Nicholas on 06 Aug 2016
  • Changed by Frank Nicholas on 06 Apr 2019
  • Changed by Imke Tammen2 on 27 Aug 2021
  • Changed by Imke Tammen2 on 17 Sep 2021