OMIA:001802-9940 : Fecundity, Davisdale, FecD in Ovis aries (sheep)
Categories: Reproductive system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal
Considered a defect: no
Key variant known: no
Inheritance: Juengel et al. (2011) reported the segregation of an autosomal gene of large effect on ovulation rate in the progeny of a single prolific ewe.
Markers: Juengel et al. (2015) investigated "if single nucleotide polymorphisms (SNPs) in the leptin receptor (LEPR) gene associated with delayed onset of puberty [Haldar et al. 2014 ] are associated with changes in other reproductive traits in adult ewes. ... The mutations in the LEPR (i.e. TT genotypes for either SNP) were associated with decreased reproductive performance in the Davisdale ewes." The authors conclude that "the effect of the LEPR mutation(s) observed, in which ovulation rate is suppressed but only in homozygous mutant animals, is inconsistent with the expected effect of the putative FECD locus, in which ovulation rate is increased in both heterozygous and homozygous animals. However, the effects of the mutation(s) in LEPR may account for the variability in the level of effects of FECD on ovulation rate, which varied between 0.4 and 0.8 additional ova released at each reproductive cycle (Juengel et al. 2011)."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2015||Juengel, J.L., French, M.C., O'Connell, A.R., Edwards, S.J., Haldar, A., Brauning, R., Farquhar, P.A., Dodds, K.G., Galloway, S.M., Johnstone, P.D., Davis, G.H. :|
|Mutations in the leptin receptor gene associated with delayed onset of puberty are also associated with decreased ovulation and lambing rates in prolific Davisdale sheep. Reprod Fertil Dev , 2015. Pubmed reference: 25688474. DOI: 10.1071/RD14382.|
|2014||Haldar, A., French, M.C., Brauning, R., Edwards, S.J., O'Connell, A.R., Farquhar, P.A., Davis, G.H., Johnstone, P.D., Juengel, J.L. :|
|Single-nucleotide polymorphisms in the LEPR gene are associated with divergent phenotypes for age at onset of puberty in Davisdale ewes. Biol Reprod 90:33, 2014. Pubmed reference: 24389871. DOI: 10.1095/biolreprod.113.115923.|
|2011||Juengel, J.L., O'Connell, A.R., French, M.C., Proctor, L.E., Wheeler, R., Farquhar, P.A., Dodds, K.G., Galloway, S.M., Johnstone, P.D., Davis, G.H. :|
|Identification of a line of sheep carrying a putative autosomal gene increasing ovulation rate in sheep that does not appear to interact with mutations in the transforming growth factor beta superfamily. Biol Reprod 85:113-20, 2011. Pubmed reference: 21415136. DOI: 10.1095/biolreprod.110.090514.|
- Created by Frank Nicholas on 04 May 2013
- Changed by Imke Tammen2 on 29 Apr 2023