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OMIA:001804-9615 : Ocular melanosis in Canis lupus familiaris

Categories: Vision / eye phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 600510 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: yes

Key variant known: no

Inheritance: Peterson-Jones et al. (2007) provided evidence of autosomal dominant inheritance in Cairn Terriers.

Molecular basis: Winkler et al. (2013) excluded 11 candidate genes in Cairn Terriers.

Breeds: Cairn Terrier, Shih-Tzu.

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Lee, E., Jeong, D., Jeong, Y., Susanti, L., Go, D.M., Seo, K., Kang, S. :
Two different procedures for managing ocular melanosis presenting scleral pigmentation with glaucoma in a Shih-Tzu dog: A case of definitive diagnosis in one eye and a presumed diagnosis in the contralateral eye. Vet Med Sci :, 2023. Pubmed reference: 36913111 . DOI: 10.1002/vms3.1111.
2013 Winkler, P.A., Bartoe, J.T., Quinones, C.R., Venta, P.J., Petersen-Jones, S.M. :
Exclusion of eleven candidate genes for ocular melanosis in Cairn terriers. J Negat Results Biomed 12:6, 2013. Pubmed reference: 23448350 . DOI: 10.1186/1477-5751-12-6.
2008 Petersen-Jones, S.M., Mentzer, A.L., Dubielzig, R.R., Render, J.A., Steficek, B.A., Kiupel, M. :
Ocular melanosis in the Cairn Terrier: histopathological description of the condition, and immunohistological and ultrastructural characterization of the characteristic pigment-laden cells. Vet Ophthalmol 11:260-8, 2008. Pubmed reference: 18638353 . DOI: 10.1111/j.1463-5224.2008.00640.x.
2007 Petersen-Jones, S.M., Forcier, J., Mentzer, A.L. :
Ocular melanosis in the Cairn Terrier: clinical description and investigation of mode of inheritance. Vet Ophthalmol 10 Suppl 1:63-9, 2007. Pubmed reference: 17973836 . DOI: 10.1111/j.1463-5224.2007.00558.x.
1991 Petersen-Jones, S.M. :
Abnormal ocular pigment deposition associated with glaucoma in the cairn terrier Journal of Small Animal Practice 32:19-22, 1991. DOI: 10.1111/j.1748-5827.1991.tb00851.x.

Edit History


  • Changed by Frank Nicholas on 13 May 2013
  • Created by Frank Nicholas on 13 May 2013
  • Changed by Imke Tammen2 on 27 Oct 2022
  • Changed by Imke Tammen2 on 18 Mar 2023