OMIA 001806-9615 : Coat colour, saddle tan vs black-and-tan in Canis lupus familiaris
However, the authors also reported that "An additional 95 dogs from breeds that never have the saddle tan phenotype have all three of the possible RALY genotypes", indicating that this variant is unlikely to be the causal variant.
Subsequently, Bannasch et al. (2021) proposed that the intronic duplication is in linkage disequilibrium with a likely causal variant in the ventral promoter of ASIP. Bannasch et al. (2021) identified a series of structural variants within 1.5 kb of the transcription start sites that are likely to affect promoter function and propose that the black saddle (BS) allele is caused by the delin g.23378062_23379640delins[MT319116.1:424_663] (CanFam3.1) in combination with an inactivated ASIP hair cycle promoter. See OMIA 000201-9615 : Coat colour, agouti in Canis lupus familiaris) for more detail.
The g.1875_1890dupCCCCAGGTCAGAGTTT (CanFam3.1; chr24: 23252754_23252770dup) variant reported by Dreger et al. (2013) is therefore more likely an indirect marker and has therefore been removed as a likely causal variant from the variant table for this phene. [8/11/2021]Breeds: Basset Hound, Pembroke Welsh Corgi. Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|ASIP||agouti signaling protein||Canis lupus familiaris||24||NC_051828.1 (24041356..24084629)||ASIP||Homologene, Ensembl, NCBI gene|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Bannasch, D.L., Kaelin, C.B., Letko, A., Loechel, R., Hug, P., Jagannathan, V., Henkel, J., Roosje, P., Hytönen, M.K., Lohi, H., Arumilli, M. :|
|Dog colour patterns explained by modular promoters of ancient canid origin. Nat Ecol Evol 5:1415-23, 2021. Pubmed reference: 34385618. DOI: 10.1038/s41559-021-01524-x.|
|Nord, M.E., Jensen, P. :|
|Genomic regions associated with variation in pigmentation loss in saddle tan Beagles. Genes (Basel) 12:316, 2021. Pubmed reference: 33672409. DOI: 10.3390/genes12020316.|
|2019||Dreger, D.L., Hooser, B.N., Hughes, A.M., Ganesan, B., Donner, J., Anderson, H., Holtvoigt, L., Ekenstedt, K.J. :|
|True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential. PLoS One 14:e0223995, 2019. Pubmed reference: 31658272. DOI: 10.1371/journal.pone.0223995.|
|2013||Dreger, D.L., Parker, H.G., Ostrander, E.A., Schmutz, S.M. :|
|Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered 104:399-406, 2013. Pubmed reference: 23519866. DOI: 10.1093/jhered/est012.|
- Created by Frank Nicholas on 13 May 2013
- Changed by Frank Nicholas on 13 May 2013
- Changed by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 08 Nov 2021
- Changed by Imke Tammen2 on 09 Nov 2021