OMIA 001807-9615 : Leishmaniasis, susceptibility/resistance to in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s) (MIM number): 602068

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: By conducting a GWAS on 115 resistant and 104 susceptible Boxer dogs, each genotyped with the Illumina CanineHD BeadChip (yielding 126,607 SNPs for analysis), Quilez et al. (2012) highlighted regions on chromosomes CFA1, 4, and 20 "although none of these were statistically significant at a genome-wide level and after correcting for genetic stratification and lifestyle".

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 de Vasconcelos, T.C.B., Furtado, M.C., Belo, V.S., Morgado, F.N., Figueiredo, F.B. :
Canine susceptibility to visceral leishmaniasis: A systematic review upon genetic aspects, considering breed factors and immunological concepts. Infect Genet Evol :, 2017. Pubmed reference: 28987807. DOI: 10.1016/j.meegid.2017.10.005.
2016 Batista, L.F., Utsunomiya, Y.T., da Silva, T.B., Dias, R.A., Tomokane, T.Y., Pacheco, A.D., da Matta, V.L., Silveira, F.T., Marcondes, M., Nunes, C.M., Laurenti, M.D. :
Genome-wide association study for cell-mediated response of dogs naturally infected by Leishmania infantum. Infect Immun :, 2016. Pubmed reference: 27736777. DOI: 10.1128/IAI.00486-16.
2015 Utsunomiya, Y.T., Ribeiro, É.S., Quintal, A.P., Sangalli, J.R., Gazola, V.R., Paula, H.B., Trinconi, C.M., Lima, V.M., Perri, S.H., Taylor, J.F., Schnabel, R.D., Sonstegard, T.S., Garcia, J.F., Nunes, C.M. :
Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling. PLoS One 10:e0136749, 2015. Pubmed reference: 26348501. DOI: 10.1371/journal.pone.0136749.
2012 Quilez, J., Martínez, V., Woolliams, J.A., Sanchez, A., Pong-Wong, R., Kennedy, L.J., Quinnell, R.J., Ollier, W.E., Roura, X., Ferrer, L., Altet, L., Francino, O. :
Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis. PLoS One 7:e35349, 2012. Pubmed reference: 22558142. DOI: 10.1371/journal.pone.0035349.
2007 Jeronimo, S.M., Duggal, P., Ettinger, N.A., Nascimento, E.T., Monteiro, G.R., Cabral, A.P., Pontes, N.N., Lacerda, H.G., Queiroz, P.V., Gomes, C.E., Pearson, R.D., Blackwell, J.M., Beaty, T.H., Wilson, M.E. :
Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan. J Infect Dis 196:1261-9, 2007. Pubmed reference: 17955446. DOI: 10.1086/521682.

Edit History


  • Created by Frank Nicholas on 20 May 2013
  • Changed by Frank Nicholas on 20 May 2013